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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders.

Ashton, Nicholas J. (author)
University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberglaboratoriet,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Wallenberg Laboratory,South London and Maudsley NHS Foundation Trust,King's College London
Hye, Abdul (author)
South London and Maudsley NHS Foundation Trust,King's College London
Rajkumar, Anto P (author)
King's College London,University of Nottingham,South London and Maudsley NHS Foundation Trust
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Leuzy, Antoine (author)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
Snowden, Stuart (author)
University of Cambridge
Suárez-Calvet, Marc (author)
University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer
Karikari, Thomas (author)
University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Schöll, Michael, 1980 (author)
University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University College London
La Joie, Renaud (author)
University of California, San Francisco
Rabinovici, Gil D (author)
University of California, San Francisco
Höglund, Kina, 1976 (author)
Karolinska Institute,University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Ballard, Clive (author)
University of Exeter
Hortobágyi, Tibor (author)
University of Debrecen,King's College London
Svenningsson, Per (author)
Karolinska Institute,Karolinska Institutet,King's College London
Blennow, Kaj, 1958 (author)
University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital
Zetterberg, Henrik, 1973 (author)
University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,University College London
Aarsland, Dag (author)
Karolinska Institutet,South London and Maudsley NHS Foundation Trust,King's College London,Stavanger University Hospital
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 (creator_code:org_t)
2020-04-22
2020
English.
In: Nature Reviews Neurology. - : Springer Science and Business Media LLC. - 1759-4766 .- 1759-4758. ; 16, s. 265-284
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  • Research review (peer-reviewed)
Abstract Subject headings
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  • Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for such pathophysiology would have greater utility in a primary care setting and in eligibility screening for clinical trials. Rapid advances in ultra-sensitive assays have enabled the levels of pathological proteins to be measured in blood samples, but research has been predominantly focused on Alzheimer disease (AD). Nonetheless, proteins that were identified as potential blood-based biomarkers for AD, for example, amyloid-β, tau, phosphorylated tau and neurofilament light chain, are likely to be relevant to other neurodegenerative disorders that involve similar pathological processes and could also be useful for the differential diagnosis of clinical symptoms. This Review outlines the neuropathological, clinical, molecular imaging and cerebrospinal fluid features of the most common neurodegenerative disorders outside the AD continuum and gives an overview of the current status of blood-based biomarkers for these disorders.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

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