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Swedish Isradipine ...
Swedish Isradipine Study in Hypertension: evaluation of quality of life, safety, and efficacy. SWISH Group.
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- Jern, Sverker, 1954 (author)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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Hansson, L (author)
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Scherstén, B (author)
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Kullman, S (author)
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Sörensen, S (author)
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- Dahlöf, Björn, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Eggertsen, Robert, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för allmänmedicin,Institute of Community Medicine, Dept of Primary Health Care
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Eivertsson, Ramon (author)
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(creator_code:org_t)
- 1991
- 1991
- English.
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In: Journal of cardiovascular pharmacology. - 0160-2446. ; 18 Suppl 3
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
Close
- This was a double-blind multicenter study to compare the efficacy, tolerability and effects on the quality of life with isradipine and atenolol in the treatment of essential hypertension. Of 588 patients entering the 6-week placebo run-in period, 549 were eligible for randomization to receive either isradipine or atenolol for 8 weeks. If, at the end of this period, diastolic blood pressure (DBP) remained greater than 90 mm Hg, then both agents were given in combination for a further 10 weeks. Tolerability and quality of life were assessed repeatedly during the placebo and active-treatment phases. A subgroup of 30 patients were followed by 24-h ambulatory blood pressure monitoring, and their results are now being analyzed. In another subgroup of 26 patients, maximum exercise capacity, as determined by ergometer bicycle-testing, was measured once during placebo and twice during active treatment. At the end of the 24-week study period, both isradipine and atenolol as monotherapy had produced significant decreases in blood pressure. There were no significant differences overall between the compounds in quality-of-life and side-effect profiles, although there was a relative absence of ankle edema and headache with isradipine. Furthermore, patients receiving isradipine had no change in performance on exercise testing whereas patients on atenolol had a significant decrease (p less than 0.01).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Antihypertensive Agents
- therapeutic use
- Atenolol
- therapeutic use
- Blood Pressure
- drug effects
- Calcium Channel Blockers
- therapeutic use
- Dihydropyridines
- therapeutic use
- Double-Blind Method
- Humans
- Hypertension
- drug therapy
- Isradipine
- Middle Aged
- Prospective Studies
- Quality of Life
- Safety
- Sweden
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jern, Sverker, 1 ...
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Hansson, L
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Scherstén, B
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Kullman, S
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Sörensen, S
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Dahlöf, Björn, 1 ...
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show more...
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Eggertsen, Rober ...
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Eivertsson, Ramo ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Journal of cardi ...
- By the university
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University of Gothenburg