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Experience-Based Sw...
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Burstrom, K.Karolinska Institute,Karolinska Institutet
(author)
Experience-Based Swedish TTO and VAS Value Sets for EQ-5D-5L Health States
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-04-20
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Springer Science and Business Media LLC,2020
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LIBRIS-ID:oai:gup.ub.gu.se/293225
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https://gup.ub.gu.se/publication/293225URI
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https://doi.org/10.1007/s40273-020-00905-7DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-165571URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143476511URI
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https://lup.lub.lu.se/record/328292e0-a6d2-44b8-b2d5-c000a9378b2bURI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|Karolinska InstitutetKarolinska Institutet
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Background and Objective Although value sets for the five-level version of the generic health-related quality-of-life instrument EQ-5D are emerging, there is still no value set available in the literature based on time trade-off valuations made by individuals experiencing the valued health states. The aim of this study was to estimate experience-based value sets for the EQ-5D-5L for Sweden using time trade-off and visual analogue scale valuation methods. Methods In a large, cross-sectional, population-based, self-administered postal health survey, the EQ-5D-5L descriptive system, EQ visual analogue scale and a time trade-off question were included. Time trade-off and visual analogue scale valuations of the respondent's current health status were used in statistical modelling to estimate a single-index value of health for each of the 3125 health states. Ordinary least-squares and generalised linear models were estimated with the main effect within each of the five dimensions represented by 20 dummy variables reflecting the additional decrement in value for levels 2-5 when the severity increases by one level sequentially beginning from having no problem. Interaction variables representing the occurrence of severity levels in at least one of the dimensions were tested: severity level 2 or worse (N2); severity level 3 or worse (N3); severity level 4 or worse (N4); severity level 5 (N5). Results A total of 896 health states (28.7% of the 3125 possible EQ-5D-5L health states) were reported by the 25,867 respondents. Visual analogue scale (n = 23,899) and time trade-off (n = 13,381) responders reported valuations of their currently experienced health state. The preferred regression models used ordinary least-squares estimation for both time trade-off and visual analogue scale values and showed consistency in all coefficients after combining certain levels. Levels 4 and 5 for the dimensions of mobility, self-care and usual activities were combined in the time trade-off model. Including the interaction variable N5, indicating severity level 5 in at least one of the five dimensions, made it possible to distinguish between the two worst severity levels where no other dimension is at level 5 as this coefficient is applied only once. In the visual analogue scale regression model, levels 4 and 5 of the mobility dimension were combined. The interaction variables N2-N4 were included, indicating that each of these terms reflect a statistically significant decrement in visual analogue scale value if any of the dimensions is at severity level 2, 3 or 4, respectively. Conclusions Time trade-off and visual analogue scale value sets for the EQ-5D-5L are now available for Sweden. The time trade-off value set is the first such value set based on experience-based time trade-off valuation. For decision makers with a preference for experience-based valuations of health states from a representative population-based sample, the reported value sets may be considered fit for purpose to support resource allocation decision as well as evaluating population health and healthcare performance.
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Teni, F. S.Karolinska Institute,Karolinska Institutet
(author)
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Gerdtham, Ulf-GLund University,Lunds universitet,Centrum för ekonomisk demografi,Ekonomihögskolan,Nationalekonomiska institutionen,Hälsoekonomi,Forskargrupper vid Lunds universitet,Centre for Economic Demography,Lund University School of Economics and Management, LUSEM,Department of Economics,Lund University School of Economics and Management, LUSEM,Health Economics,Lund University Research Groups(Swepub:lu)smi-uge
(author)
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Leidl, R.German Res Ctr Environm Hlth, Germany; Ludwig Maximilians Univ Munchen, Germany,Ludwig-Maximilian University of Munich
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Helgesson, G.Karolinska Institute,Karolinska Institutet
(author)
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Rolfson, Ola,1973Karolinska Institute,University of Gothenburg,Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics,Karolinska Inst, Sweden; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden; Ctr Registers Vastra Gotaland, Sweden,Swedish Hip Arthroplasty Register,Sahlgrenska University Hospital(Swepub:gu)xrolol
(author)
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Henriksson, MartinLinköping University,Linköpings universitet,Avdelningen för samhälle och hälsa,Medicinska fakulteten(Swepub:liu)marhe38
(author)
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Karolinska InstituteKarolinska Institutet
(creator_code:org_t)
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In:Pharmacoeconomics: Springer Science and Business Media LLC38, s. 839-8561170-76901179-2027
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