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Preoperative antibi...
Preoperative antibiotic prophylaxis regimen in brain tumour surgery in Sweden: a quasi-experimental study.
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-05-07
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Springer Science and Business Media LLC,2020
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/293371
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https://gup.ub.gu.se/publication/293371URI
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https://doi.org/10.1007/s00701-020-04309-6DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143614919URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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There has been varied clinical practice concerning antibiotic prophylaxis in patients undergoing craniotomy. In Sweden, both Cloxacillin and Cefuroxime have frequently been used. We aimed to study the clinical effectiveness of these two regimens.A quasi-experimental design was used. The sample consisted of 580 adult (>18years) patients operated 2012-2015, of which 375 received Cloxacillin (pre-intervention group) and 205 received Cefuroxime (intervention group). Primary endpoint was the incidence of surgical site infection (SSI) 12months after surgery, while secondary endpoints were the need for reoperation due to SSI, the amount antibiotics used and the number of visits in the outpatient clinic related to SSI. A control group from another institution was reviewed to rule out clinical trial effects.When analysed by intention to treat, the pre-intervention group had a significant higher incidence of SSI, 13.3% (50/375) vs 5.4% (11/205) in the intervention group (p<0.01). A treatment per protocol analysis confirmed the result. The number of reoperations due to SSI were significantly reduced in the intervention group, 3.4% (7/205) vs 8.3% (31/375) (p=0.02), as was the total antibiotic use (p=0.03) and the number of visits in the outpatient clinic (p<0.01). In the control group, the reoperation rate as result of SSI was lower (p=0.02) prior to the opposite change from Cefuroxime to Cloxacillin, 1.8% (27/1529) vs 3.1% (43/1378).In Sweden, Cefuroxime as prophylaxis in brain tumour surgery by craniotomy seems to be superior to Cloxacillin.
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Bartek, JiriKarolinska Institutet
(author)
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Haghighi, Maryam
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Fornebo, Ida
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Skoglund, Thomas,1969Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xskoth
(author)
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Jakola, Asgeir StoreGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xjakas
(author)
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von Vogelsang, Ann-ChristinKarolinska Institutet
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Förander, PetterKarolinska Institutet
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
(creator_code:org_t)
Related titles
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In:Acta neurochirurgica: Springer Science and Business Media LLC162, s. 2849-28560942-09400001-6268
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