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Cellular Analysis a...
Cellular Analysis and Comparative Transcriptomics Reveal the Tolerance Mechanisms of Candida tropicalis Toward Phenol
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Wang, H. Y. (author)
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Li, Q. (author)
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Peng, Y. Y. (author)
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Zhang, Z. Y. (author)
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Kuang, X. L. (author)
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Hu, X. D. (author)
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Ayepa, E. (author)
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Han, X. B. (author)
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Abrha, G. T. (author)
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Xiang, Q. J. (author)
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Yu, X. M. (author)
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Zhao, K. (author)
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Zou, L. K. (author)
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Gu, Y. F. (author)
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Li, X. (author)
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Li, X. Y. (author)
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Chen, Q. (author)
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Zhang, X. P. (author)
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- Liu, Beidong, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Ma, M. G. (author)
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(creator_code:org_t)
- 2020-04-15
- 2020
- English.
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In: Frontiers in Microbiology. - : Frontiers Media SA. - 1664-302X. ; 11
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Abstract
Subject headings
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- Phenol is a ubiquitous pollutant and can contaminate natural water resources. Hence, the removal of phenol from wastewater is of significant importance. A series of biological methods were used to remove phenol based on the natural ability of microorganisms to degrade phenol, but the tolerance mechanism of phenol-degraded strains to phenol are not very clear. Morphological observation on Candida tropicalis showed that phenol caused the reactive oxygen species (ROS) accumulation, damaging the mitochondrial and the endoplasmic reticulum. On the basis of transcriptome data and cell wall susceptibility analysis, it was found that C. tropicalis prevented phenol-caused cell damage through improvement of cell wall resistance, maintenance of high-fidelity DNA replication, intracellular protein homeostasis, organelle integrity, and kept the intracellular phenol concentration at a low level through cell-wall remodeling and removal of excess phenol via MDR/MXR transporters. The knowledge obtained will promote the genetic modification of yeast strains in general to tolerate the high concentrations of phenol and improve their efficiency of phenol degradation.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- Candida tropicalis
- morphological observation
- phenol
- reactive oxygen
- species (ROS)
- tolerance mechanism
- transcriptome
- saccharomyces-cerevisiae
- rhodococcus-opacus
- waste-water
- fatty-acid
- yeast
- protein
- identification
- chitin
- damage
- growth
- Microbiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wang, H. Y.
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Li, Q.
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Peng, Y. Y.
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Zhang, Z. Y.
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Kuang, X. L.
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Hu, X. D.
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show more...
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Ayepa, E.
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Han, X. B.
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Abrha, G. T.
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Xiang, Q. J.
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Yu, X. M.
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Zhao, K.
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Zou, L. K.
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Gu, Y. F.
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Li, X.
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Li, X. Y.
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Chen, Q.
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Zhang, X. P.
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Liu, Beidong, 19 ...
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Ma, M. G.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
- Articles in the publication
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Frontiers in Mic ...
- By the university
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University of Gothenburg