Search: onr:"swepub:oai:gup.ub.gu.se/293746" >
Genetic variants in...
Genetic variants in the MTHFR are not associated with fatty liver disease.
-
De Vincentis, Antonio (author)
-
- Mancina, Rosellina Margherita (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
Philamajäki, Jussi (author)
-
show more...
-
Männiströ, Ville (author)
-
Petta, Salvatore (author)
-
Dongiovanni, Paola (author)
-
Fracanzani, Anna (author)
-
Valenti, Luca (author)
-
Tavaglione, Federica (author)
-
- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
Vespasiani-Gentilucci, Umberto (author)
-
show less...
-
(creator_code:org_t)
- 2020-06-11
- 2020
- English.
-
In: Liver international : official journal of the International Association for the Study of the Liver. - : Wiley. - 1478-3231. ; 40:8, s. 1934-1940
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The common missense sequence variants of methylenetetrahydrofolate-reductase (MTHFR), rs1801131 (c.A1298C) and rs1801133 (c.C677T), favor the development of hyperhomocysteinemia and diminished DNA methylation. Previous studies, carried out in small series and with suboptimal characterization of the hepatic phenotype, tested the association of these genetic variants with fatty liver disease (FLD), with conflicting results. Here, we assessed the association of rs1801131 and rs1801133 with hepatic phenotype in the Liver Biopsy Cross-Sectional Cohort, a large cohort (n=1375 from Italy and 411 from Finland) of European individuals with suspect FLD associated with dysmetabolism. A total of 1786 subjects were analyzed by ordinal regression analyses. The rs1801131 and the rs1801133 variants were not associated with steatosis, inflammation, ballooning, or fibrosis. The present study suggests that changes in folate and methionine metabolism resulting from these 2 variants are not associated with a clinically significant impact on FLD in Europeans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
De Vincentis, An ...
-
Mancina, Roselli ...
-
Philamajäki, Jus ...
-
Männiströ, Ville
-
Petta, Salvatore
-
Dongiovanni, Pao ...
-
show more...
-
Fracanzani, Anna
-
Valenti, Luca
-
Tavaglione, Fede ...
-
Romeo, Stefano, ...
-
Vespasiani-Genti ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Liver internatio ...
-
Liver Internatio ...
- By the university
-
University of Gothenburg