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Self-reported Sleep...
Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression
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Fjell, A. M. (author)
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Sederevicius, D. (author)
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Sneve, M. H. (author)
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De Lange, A. M. G. (author)
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Brathen, A. C. (author)
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Idland, A. V. (author)
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Watne, L. O. (author)
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Wang, Y. P. (author)
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Reinbold, C. (author)
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Dobricic, V. (author)
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Kilpert, F. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Hong, S. J. (author)
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Bertram, L. (author)
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Walhovd, K. B. (author)
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(creator_code:org_t)
- 2019-11-11
- 2020
- English.
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In: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 30:4, s. 2144-2156
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Sleep problems are related to the elevated levels of the Alzheimer's disease (AD) biomarker beta-amyloid (AD) Hypotheses about the causes of this relationship can be generated from molecular markers of sleep problems identified in rodents. A major marker of sleep deprivation is Homerla, a neural protein coded by the HOMER1 gene, which has also been implicated in brain A beta accumulation. Here, we tested whether the relationship between cortical A beta accumulation and self-reported sleep quality, as well as changes in sleep quality over 3 years, was stronger in cortical regions with high HOMER1 mRNA expression levels. In a sample of 154 cognitively healthy older adults, A beta correlated with poorer sleep quality cross-sectionally and longitudinally (n = 62), but more strongly in the younger than in older individuals. Effects were mainly found in regions with high expression of HOMER1. The anatomical distribution of the sleep-A beta relationship followed closely the A beta accumulation pattern in 69 patients with mild cognitive impairment or AD. Thus, the results indicate that the relationship between sleep problems and A beta accumulation may involve Homer1 activity in the cortical regions, where harbor A beta deposits in AD. The findings may advance our understanding of the relationship between sleep problems and AD risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid
- gene expression
- HOMER1
- sleep
- surface-based analysis
- alzheimers-disease
- cerebral-cortex
- hypothetical model
- quality
- beta
- thickness
- protein
- body
- neuroinflammation
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fjell, A. M.
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Sederevicius, D.
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Sneve, M. H.
-
De Lange, A. M. ...
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Brathen, A. C.
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Idland, A. V.
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show more...
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Watne, L. O.
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Wang, Y. P.
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Reinbold, C.
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Dobricic, V.
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Kilpert, F.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Hong, S. J.
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Bertram, L.
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Walhovd, K. B.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Cerebral Cortex
- By the university
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University of Gothenburg