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The mitogen-activat...
The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1
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- Ahmadpour, Doryaneh, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Maciaszczyk-Dziubinska, Ewa (author)
- Uniwersytet Wrocławski,University of Wrocław
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- Babazadeh, Roja (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Dahal, Sita, 1985 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Migocka, Magdalena (author)
- Uniwersytet Wrocławski,University of Wrocław
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- Andersson, Mikael (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Wysocki, Robert (author)
- Uniwersytet Wrocławski,University of Wrocław
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- Tamás, Markus J., 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Hohmann, Stefan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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(creator_code:org_t)
- 2016-09-28
- 2016
- English.
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In: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 590:20, s. 3649-3659
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Abstract
Subject headings
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- © 2016 Federation of European Biochemical Societies Arsenite is widely present in nature; therefore, cells have evolved mechanisms to prevent arsenite influx and promote efflux. In yeast (Saccharomyces cerevisiae), the aquaglyceroporin Fps1 mediates arsenite influx and efflux. The mitogen-activated protein kinase (MAPK) Hog1 has previously been shown to restrict arsenite influx through Fps1. In this study, we show that another MAPK, Slt2, is transiently phosphorylated in response to arsenite influx. Our findings indicate that the protein kinase activity of Slt2 is required for its role in arsenite tolerance. While Hog1 prevents arsenite influx via phosphorylation of T231 at the N-terminal domain of Fps1, Slt2 promotes arsenite efflux through phosphorylation of S537 at the C terminus. Our data suggest that Slt2 physically interacts with Fps1 and that this interaction depends on phosphorylation of S537. We hypothesize that Hog1 and Slt2 may affect each other's binding to Fps1, thereby controlling the opening and closing of the channel.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- arsenite
- mitogen-activated protein kinase
- signal transduction
- stress response
- transmembrane transport
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ahmadpour, Dorya ...
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Maciaszczyk-Dziu ...
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Babazadeh, Roja
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Dahal, Sita, 198 ...
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Migocka, Magdale ...
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Andersson, Mikae ...
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show more...
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Wysocki, Robert
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Tamás, Markus J. ...
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Hohmann, Stefan, ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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FEBS Letters
- By the university
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University of Gothenburg
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Chalmers University of Technology