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Risk of Metastasis ...
Risk of Metastasis in Men with Grade Group 2 Prostate Cancer Managed with Active Surveillance at a Tertiary Cancer Center
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- Carlsson, Sigrid, 1982 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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Benfante, N. (author)
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Alvim, R. (author)
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Sjoberg, D. D. (author)
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Vickers, A. (author)
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Reuter, V. E. (author)
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Fine, S. W. (author)
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Vargas, H. A. (author)
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Wiseman, M. (author)
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Mamoor, M. (author)
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Ehdaie, B. (author)
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Laudone, V. (author)
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Scardino, P. (author)
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Eastham, J. (author)
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Touijer, K. (author)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2020
- 2020
- English.
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In: Journal of Urology. - : Ovid Technologies (Wolters Kluwer Health). - 0022-5347 .- 1527-3792. ; 203:6, s. 1117-1121
- Related links:
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https://www.ncbi.nlm...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Purpose: We studied the risk of metastatic prostate cancer development in men with Grade Group 2 disease managed with active surveillance at Memorial Sloan Kettering Cancer Center. Materials and Methods: A total of 219 men with Grade Group 2 prostate cancer had disease managed with active surveillance between 2000 and 2017. Biopsy was performed every 2 to 3 years, or upon changes in magnetic resonance imaging, prostate specific antigen level or digital rectal examination. The primary outcome was development of distant metastasis. The Kaplan-Meier method was used to estimate treatment-free survival. Results: Median age at diagnosis was 67 years (IQR 61-72), median prostate specific antigen was 5 ng/ml (IQR 4-7) and most patients (69%) had nonpalpable disease. During followup 64 men received treatment, including radical prostatectomy in 36 (56%), radiotherapy in 20 (31%), hormone therapy in 3 (5%) and focal therapy in 5 (8%). Of the 36 patients who underwent radical prostatectomy 32 (89%) had Grade Group 2 disease on pathology and 4 (11%) had Grade Group 3 disease. Treatment-free survival was 61% (95% CI 52-70) at 5 years and 49% (95% CI 37-60) at 10 years. Three men experienced biochemical recurrence, no men had distant metastasis and no men died of prostate cancer during the followup. Median followup was 3.1 years (IQR 1.9-4.9). Conclusions: Active surveillance appears to be a safe initial management strategy in the short term for carefully selected and closely monitored men with Grade Group 2 prostate cancer treated at a tertiary cancer center. Definitive conclusions await further followup.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- prostatic neoplasms
- watchful waiting
- neoplasm grading
- term outcomes
- follow-up
- intermediate
- worldwide
- cohort
- Urology & Nephrology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Carlsson, Sigrid ...
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Benfante, N.
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Alvim, R.
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Sjoberg, D. D.
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Vickers, A.
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Reuter, V. E.
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show more...
-
Fine, S. W.
-
Vargas, H. A.
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Wiseman, M.
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Mamoor, M.
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Ehdaie, B.
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Laudone, V.
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Scardino, P.
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Eastham, J.
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Touijer, K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Journal of Urolo ...
- By the university
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University of Gothenburg