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- Morcos, M. N. F.Dresden University of Technology (author)
Continuous mitotic activity of primitive hematopoietic stem cells in adult mice
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-04-16
- Rockefeller University Press,2020
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/294387
- https://gup.ub.gu.se/publication/294387URI
- https://doi.org/10.1084/jem.20191284DOI
- https://lup.lub.lu.se/record/87dd476f-c8f9-4524-a38e-5ec0e10477a1URI
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- Language:English
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- SwePubSwePub
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Notes
- The proliferative activity of aging hematopoietic stem cells (HSCs) is controversially discussed. Inducible fluorescent histone 2B fusion protein (H2B-FP) transgenic mice are important tools for tracking the mitotic history of murine HSCs in label dilution experiments. A recent study proposed that primitive HSCs symmetrically divide only four times to then enter permanent quiescence. We observed that background fluorescence due to leaky H2B-FP expression, occurring in all H2B-FP transgenes independent of label induction, accumulated with age in HSCs with high repopulation potential. We argue that this background had been misinterpreted as stable retention of induced label. We found cell division-independent half-lives of H2B-FPs to be short, which had led to overestimation of HSC divisional activity. Our data do not support abrupt entry of HSCs into permanent quiescence or sudden loss of regeneration potential after four divisions, but show that primitive HSCs of adult mice continue to cycle rarely.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
- self-renewal
- gene-expression
- dynamics
- exchange
- proliferation
- heterogeneity
- history
- cd34
- h3
- Immunology
- Research & Experimental Medicine
Added entries (persons, corporate bodies, meetings, titles ...)
- Zerjatke, T.Dresden University of Technology (author)
- Glauche, I.Dresden University of Technology (author)
- Munz, C. M.Dresden University of Technology (author)
- Ge, Y.Dresden University of Technology (author)
- Petzold, A.Dresden University of Technology (author)
- Reinhardt, S.Dresden University of Technology (author)
- Dahl, A.Dresden University of Technology (author)
- Anstee, N. S.German Cancer Research Centre (author)
- Bogeska, R.German Cancer Research Centre (author)
- Milsom, M. D.German Cancer Research Centre (author)
- Säwén, PetterLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Utvecklingshematopoes,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Developmental Hematopoiesis,Lund University Research Groups(Swepub:lu)stem-psa (author)
- Wan, HaixiaLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Utvecklingshematopoes,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Developmental Hematopoiesis,Lund University Research Groups(Swepub:lu)med-hxw (author)
- Bryder, DavidUniversity of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Utvecklingshematopoes,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Developmental Hematopoiesis,Lund University Research Groups(Swepub:lu)med-dbr (author)
- Roers, A.Dresden University of Technology (author)
- Gerbaulet, A.Dresden University of Technology (author)
- Dresden University of TechnologyGerman Cancer Research Centre (creator_code:org_t)
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- In:Journal of Experimental Medicine: Rockefeller University Press217:60022-10071540-9538
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- Reinhardt, S.
- Dahl, A.
- Anstee, N. S.
- Bogeska, R.
- Milsom, M. D.
- Säwén, Petter
- Wan, Haixia
- Bryder, David
- Roers, A.
- Gerbaulet, A.
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