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Effects of C-Peptid...
Effects of C-Peptide Replacement Therapy on Bone Microarchitecture Parameters in Streptozotocin-Diabetic Rats.
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Maurotti, Samantha (author)
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Russo, Cristina (author)
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Musolino, Vincenzo (author)
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Nucera, Saverio (author)
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Gliozzi, Micaela (author)
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Scicchitano, Miriam (author)
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Bosco, Francesca (author)
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Morittu, Valeria Maria (author)
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Ragusa, Monica (author)
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Mazza, Elisa (author)
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Pujia, Roberta (author)
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Gazzaruso, Carmine (author)
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Britti, Domenico (author)
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Valenti, Maria Teresa (author)
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Deiana, Michela (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Giannini, Sandro (author)
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Dalle Carbonare, Luca (author)
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Mollace, Vincenzo (author)
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Pujia, Arturo (author)
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Montalcini, Tiziana (author)
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(creator_code:org_t)
- 2020-06-30
- 2020
- English.
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In: Calcified tissue international. - : Springer Science and Business Media LLC. - 1432-0827 .- 0171-967X. ; 107, s. 266-280
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Abstract
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- C-peptide therapy protects against diabetic micro- and macrovascular damages and neuropatic complications. However, to date, the role of C-peptide in preventing diabetes-related bone loss has not been investigated. Our aim was to evaluate if C-peptide infusion improves bone quality in diabetic rats. Twenty-three male Wistar rats were randomly divided into three groups: normal control group; sham diabetic control group; diabetic plus C-peptide group. Diabetes was induced by streptozotocin injection and C-peptide was delivered subcutaneously for 6weeks. We performed micro-CT and histological testing to assess several trabecular microarchitectural parameters. At the end, diabetic plus C-peptide rats had a higher serum C-peptide (p=0.02) and calcium (p=0.04) levels and tibia weight (p=0.02) than the diabetic control group. The diabetic plus C-peptide group showed a higher trabecular thickness and cross-sectional thickness than the diabetic control group (p=0.01 and p=0.03). Both the normal control and diabetic plus C-peptide groups had more Runx-2 and PLIN1 positive cells in comparison with the diabetic control group (p=0.045 and p=0.034). Diabetic rats receiving C-peptidehad higher quality of trabecular bone than diabetic rats not receiving this treatment. If confirmed, C-peptide could have a role in improving bone quality in diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Maurotti, Samant ...
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Russo, Cristina
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Musolino, Vincen ...
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Nucera, Saverio
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Gliozzi, Micaela
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Scicchitano, Mir ...
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show more...
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Bosco, Francesca
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Morittu, Valeria ...
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Ragusa, Monica
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Mazza, Elisa
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Pujia, Roberta
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Gazzaruso, Carmi ...
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Britti, Domenico
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Valenti, Maria T ...
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Deiana, Michela
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Romeo, Stefano, ...
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Giannini, Sandro
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Dalle Carbonare, ...
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Mollace, Vincenz ...
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Pujia, Arturo
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Montalcini, Tizi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Calcified tissue ...
- By the university
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University of Gothenburg