onr:"swepub:oai:gup.ub.gu.se/294615"
Search: onr:"swepub:oai:gup.ub.gu.se/294615" > Ultrasensitive and ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Ultrasensitive and Selective Copper(II) Detection: Introducing a Bioinspired and Robust Sensor
- Muller, L. K. (author)
- Duznovic, I. (author)
-
- Tietze, Daniel, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
- show more...
- Weber, W. (author)
- Ali, M. (author)
- Stein, V. (author)
- Ensinger, W. (author)
- show less...
- (creator_code:org_t)
- 2020-06-17
- 2020
- English.
- In: Chemistry-a European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 26:39, s. 8511-8517
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- A nanopore-based Cu-II-sensing system is reported that allows for an ultrasensitive and selective detection of Cu(II)with the possibility for a broad range of applications, for example in medical diagnostics. A fluorescent ATCUN-like peptide 5/6-FAM-Dap-beta-Ala-His is employed to selectively bind Cu(II)ions in the presence of Ni(II)and Zn(II)and was crafted into ion track-etched nanopores. Upon Cu(II)binding the fluorescence of the peptide sensor is quenched, permitting the detection of Cu(II)in solution. The ion transport characteristics of peptide-modified nanopore are shown to be extremely sensitive and selective towards Cu(II)allowing to sense femtomolar Cu(II)concentrations in human urine mimics. Washing with EDTA fully restores the Cu-II-binding properties of the sensor, enabling multiple repetitive measurements. The robustness of the system clearly has the potential to be further developed into an easy-to-use, lab-on-chip Cu-II-sensing device, which will be of great importance for bedside diagnosis and monitor of Cu(II)levels in patients with copper-dysfunctional homeostasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- ATCUN
- copper
- fluorescence
- nanopores
- sensors
- metal-binding
- alzheimers-disease
- nanopore sensor
- atcun motif
- cu(ii)
- serum
- ions
- peptides
- design
- Chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Chemistry-a European Journal (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Muller, L. K.
- Duznovic, I.
- Tietze, Daniel, ...
- Weber, W.
- Ali, M.
- Stein, V.
- show more...
- Ensinger, W.
- Tietze, Alesia A ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Chemistry-a Euro ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
