Search: onr:"swepub:oai:gup.ub.gu.se/294758" >
Improvement in the ...
Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach
-
- Ozcan, Mehmet (author)
- KTH,Science for Life Laboratory, SciLifeLab,Hacettepe University, Ankara, 06100, Turkey
-
- Altay, Özlem (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
- Lam, S. (author)
- King's College London
-
show more...
-
- Turkez, H. (author)
- Atatürk Üniversitesi,Atatürk University
-
- Aksoy, Y. (author)
- Hacettepe Üniversitesi,Hacettepe University
-
- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg
-
- Mardinoglu, Adil, 1982 (author)
- KTH,Science for Life Laboratory, SciLifeLab,Craniofacial Sciences, King’s College London, London
-
show less...
-
(creator_code:org_t)
- 2020-04-08
- 2020
- English.
-
In: Advanced Biosystems. - : Wiley. - 2366-7478. ; 4:6
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death primarily due to the lack of effective targeted therapies. Despite the distinct morphological and phenotypic patterns of HCC, treatment strategies are restricted to relatively homogeneous therapies, including multitargeted tyrosine kinase inhibitors and immune checkpoint inhibitors. Therefore, more effective therapy options are needed to target dysregulated metabolic and molecular pathways in HCC. Integrative genomic profiling of HCC patients provides insight into the most frequently mutated genes and molecular targets, including telomerase reverse transcriptase, the TP53 gene, and the Wnt/β-catenin signaling pathway oncogene (CTNNB1). Moreover, emerging techniques, such as genome-scale metabolic models may elucidate the underlying cancer-specific metabolism, which allows for the discovery of potential drug targets and identification of biomarkers. De novo lipogenesis has been revealed as consistently upregulated since it is required for cell proliferation in all HCC patients. The metabolic network-driven stratification of HCC patients in terms of redox responses, utilization of metabolites, and subtype-specific pathways may have clinical implications to drive the development of personalized medicine. In this review, the current and emerging therapeutic targets in light of molecular approaches and metabolic network-based strategies are summarized, prompting effective treatment of HCC patients. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- genome scale metabolic models
- hepatocellular carcinoma
- molecular‑targeted therapies
- network-driven stratification
- systemic therapies
- Amino acids
- Cell proliferation
- Diseases
- Genes
- Metabolism
- Metabolites
- Personalized medicine
- Genome scale metabolic model
- Molecular approach
- Molecular pathways
- Potential drug targets
- Telomerase reverse transcriptase
- Therapeutic targets
- Tyrosine kinase inhibitor
- Patient treatment
- hepatocellular carcinoma
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ozcan, Mehmet
-
Altay, Özlem
-
Lam, S.
-
Turkez, H.
-
Aksoy, Y.
-
Nielsen, Jens B, ...
-
show more...
-
Uhlén, Mathias
-
Borén, Jan, 1963
-
Mardinoglu, Adil ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Advanced Biosyst ...
- By the university
-
University of Gothenburg
-
Chalmers University of Technology
-
Royal Institute of Technology