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Recurrent horizonta...
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-06-16
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Springer Science and Business Media LLC,2020
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/294859
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https://gup.ub.gu.se/publication/294859URI
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https://doi.org/10.1038/s41467-020-16765-wDOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Nicholls, Thomas J.Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
(author)
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Baez-Ortega, A.
(author)
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Ni Leathlobhair, M.
(author)
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Sampson, A. T.
(author)
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Hughes, K.
(author)
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Bolton, I. A. G.
(author)
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Gori, K.
(author)
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Wang, J. H.
(author)
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Airikkala-Otter, I.
(author)
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Allen, J. L.
(author)
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Allum, K. M.
(author)
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Arnold, C. L.
(author)
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Bansse-Issa, L.
(author)
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Bhutia, T. N.
(author)
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Bisson, J. L.
(author)
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Blank, K.
(author)
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Briceno, C.
(author)
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Domracheva, A. C.
(author)
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Corrigan, A. M.
(author)
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Cran, H. R.
(author)
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Crawford, J. T.
(author)
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Cutter, S. M.
(author)
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Davis, E.
(author)
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de Castro, K. F.
(author)
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De Nardi, A. B.
(author)
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de Vos, A. P.
(author)
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Keena, L. D.
(author)
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Donelan, E. M.
(author)
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Huerta, A. R. E.
(author)
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Faramade, I. A.
(author)
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Fazil, M.
(author)
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Fotopoulou, E.
(author)
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Fruean, S. N.
(author)
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Gallardo-Arrieta, F.
(author)
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Glebova, O.
(author)
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Gouletsou, P. G.
(author)
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Hafelin Manrique, R. F.
(author)
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Henriques, Jjgp
(author)
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Horta, R. S.
(author)
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Ignatenko, N.
(author)
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Kane, Y.
(author)
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King, C.
(author)
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Koenig, D.
(author)
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Krupa, A.
(author)
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Kruzeniski, S. J.
(author)
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Lanza-Perea, M.
(author)
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Lazyan, M.
(author)
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Quintana, A. M. L.
(author)
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Losfelt, T.
(author)
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Marino, G.
(author)
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Martinez Castaneda, S.
(author)
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Martinez-Lopez, M. F.
(author)
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Masuruli, B. M.
(author)
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Meyer, M.
(author)
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Migneco, E. J.
(author)
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Nakanwagi, B.
(author)
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Neal, K. B.
(author)
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Neunzig, W.
(author)
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Nixon, S. J.
(author)
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Ortega-Pacheco, A.
(author)
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Pedraza-Ordonez, F.
(author)
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Peleteiro, M. C.
(author)
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Polak, K.
(author)
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Pye, R. J.
(author)
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Ramirez-Ante, J. C.
(author)
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Reece, J. F.
(author)
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Gutierrez, J. R.
(author)
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Sadia, H.
(author)
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Schmeling, S. K.
(author)
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Shamanova, O.
(author)
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Sherlock, A. G.
(author)
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Steenland-Smit, A. E.
(author)
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Svitich, A.
(author)
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Tapia Martinez, L. J.
(author)
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Ngoka, I. T.
(author)
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Torres, C. G.
(author)
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Tudor, E. M.
(author)
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van der Wel, M. G.
(author)
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Vitalaru, B. A.
(author)
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Vural, S. A.
(author)
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Walkinton, O.
(author)
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Wehrle-Martinez, A. S.
(author)
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Widdowson, S. A. E.
(author)
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Zvarich, I.
(author)
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Chinnery, P. F.
(author)
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Falkenberg, M.
(author)
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Gustafsson, C. M.
(author)
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Murchison, E. P.
(author)
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Göteborgs universitetInstitutionen för biomedicin
(creator_code:org_t)
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In:Nature Communications: Springer Science and Business Media LLC112041-1723
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Strakova, A.
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- MEDICAL AND HEALTH SCIENCES
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