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Putative Cut-Points...
Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: AnSDOCAnalysis
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- Cawthon, P. M. (author)
- Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.,California Pacific Medical Center,University of California, San Francisco
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- Manini, T. (author)
- Univ Florida, Gainesville, FL USA.,University of Florida
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- Patel, S. M. (author)
- Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA.,NIA, Longitudinal Studies Sect, Baltimore, MD 21224 USA.,California Pacific Medical Center,National Institute on Aging, United States
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- Newman, A. (author)
- Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.,University of Pittsburgh
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- Travison, T. (author)
- Beth Israel Deaconess Med Ctr, Dept Med, Marcus Inst Aging Res, Hebrew SeniorLife, Boston, MA 02215 USA.;Harvard Med Sch, Boston, MA 02115 USA.,Harvard Medical School
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- Kiel, D. P. (author)
- Beth Israel Deaconess Med Ctr, Dept Med, Marcus Inst Aging Res, Hebrew SeniorLife, Boston, MA 02215 USA.;Harvard Med Sch, Boston, MA 02115 USA.,Harvard Medical School
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- Santanasto, A. J. (author)
- Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.,University of Pittsburgh
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- Ensrud, K. E. (author)
- Minneapolis VA Hlth Care Syst, Ctr Chron Dis Outcomes Res, Minneapolis, MN USA.;Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA.,University of Minnesota
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- Xue, Q. L. (author)
- Johns Hopkins Med Inst, Div Geriatr Med & Gerontol, Baltimore, MD 21205 USA.;Johns Hopkins Med Inst, Ctr Aging & Hlth, Baltimore, MD 21205 USA.,Johns Hopkins Hospital
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Shardell, M. (author)
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- Duchowny, K. (author)
- Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.,University of California, San Francisco
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- Karlsson, Magnus (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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- Pencina, K. M. (author)
- Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.,University of Pittsburgh
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- Fielding, R. A. (author)
- Tufts Univ, Jean Mayer US Dept Agr Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA.,Tufts University
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- Magaziner, J. (author)
- Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA.,Slotervaart Hospital
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- Kwok, T. (author)
- Chinese Univ Hong Kong, Dept Med & Therapeut, Fac Med, Shatin, Hong Kong, Peoples R China.;Chinese Univ Hong Kong, Sch Publ Hlth, Fac Med, Shatin, Hong Kong, Peoples R China.,Chinese University of Hong Kong
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Karlsson, M. (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Dept Internal Med & Clin Nutr,Inst Med, Gothenburg, Sweden.,Sahlgrenska Academy
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Dept Internal Med & Clin Nutr,Inst Med, Gothenburg, Sweden.,Sahlgrenska Academy
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- Hirani, V. (author)
- Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia.,University of Sydney
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- Ribom, Eva L (author)
- Uppsala University,Uppsala universitet,Ortopedi
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- Correa-de-Araujo, R. (author)
- NIA, Bethesda, MD 20892 USA.
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- Bhasin, S. (author)
- Harvard Med Sch, Boston Claude D Pepper Older Americans Independen, Brigham & Womens Hosp, Boston, MA 02115 USA.,Harvard Medical School
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Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA. California Pacific Medical Center (creator_code:org_t)
- 2020-07-07
- 2020
- English.
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In: Journal of the American Geriatrics Society. - : Wiley. - 0002-8614 .- 1532-5415. ; 68:7, s. 1429-1437
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVES Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht(2)); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality). DESIGN Individual-level, sex-stratified pooled analysis. We calculated odds ratios (ORs) or hazard ratios (HRs) for incident falls, mobility limitation, hip fractures, and mortality. Follow-up time ranged from 1 year for falls to 8.8 +/- 2.3 years for mortality. SETTING Eight prospective observational cohort studies. PARTICIPANTS A total of 13,421 community-dwelling men and 4,828 community-dwelling women. MEASUREMENTS Grip strength by hand dynamometry, gait speed, and lean mass by DXA. RESULTS Low grip strength (absolute or standardized to body size/composition) was associated with incident outcomes, usually independently of slowness, in both men and women. ORs and HRs generally ranged from 1.2 to 3.0 for those below vs above the cut-point. DXA lean mass was not consistently associated with these outcomes. When considered together, those who had both muscle weakness by absolute grip strength (<35.5 kg in men and <20 kg in women) and slowness were consistently more likely to have a fall, hip fracture, mobility limitation, or die than those without either slowness or muscle weakness. CONCLUSION Older men and women with both muscle weakness and slowness have a higher likelihood of adverse health outcomes. These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- sarcopenia
- grip strength
- gait speed
- hip fracture
- mobility limitation
- grip strength
- gait speed
- predictor
- consensus
- adults
- age
- Geriatrics & Gerontology
- sarcopenia
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Cawthon, P. M.
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Manini, T.
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Patel, S. M.
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Newman, A.
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Travison, T.
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Kiel, D. P.
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Santanasto, A. J ...
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Ensrud, K. E.
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Xue, Q. L.
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Shardell, M.
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Duchowny, K.
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Karlsson, Magnus
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Pencina, K. M.
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Fielding, R. A.
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Magaziner, J.
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Kwok, T.
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Karlsson, M.
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Ohlsson, Claes, ...
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Mellström, Dan, ...
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Hirani, V.
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Ribom, Eva L
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Correa-de-Araujo ...
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Bhasin, S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Journal of the A ...
- By the university
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University of Gothenburg
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Uppsala University
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Lund University