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A multi-center stud...
A multi-center study of neurofilament assay reliability and inter-laboratory variability
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Gray, E. (author)
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Oeckl, P. (author)
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Amador, M. D. M. (author)
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- Andreasson, Ulf, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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An, J. Y. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Bowser, R. (author)
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De Schaepdryver, M. (author)
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Heslegrave, A. (author)
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Kuhle, J. (author)
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Maceski, A. (author)
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Koel-Simmelink, M. (author)
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Lamari, F. (author)
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Lombardi, V. (author)
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Malaspina, A. (author)
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- Nilsson, Irina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Poesen, K. (author)
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Salachas, F. (author)
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Steinacker, P. (author)
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Teunissen, C. E. (author)
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Van Damme, P. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Ludolph, A. (author)
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Jeromin, A. (author)
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Turner, M. R. (author)
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Otto, M. (author)
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(creator_code:org_t)
- 2020-06-19
- 2020
- English.
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In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. - : Informa UK Limited. - 2167-8421 .- 2167-9223. ; 21:5-6, s. 452-458
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https://lirias.kuleu...
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Abstract
Subject headings
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- Objectives: Significantly elevated levels of neurofilament light chain (NfL) and phosphorylated neurofilament heavy chain (pNfH) have been described in the blood and cerebrospinal fluid (CSF) of amyotrophic lateral sclerosis (ALS) patients. The aim of this study was to evaluate the analytical performance of different neurofilament assays in a round robin with 10 centers across Europe/U.S.Methods: Serum, plasma and CSF samples from a group of five ALS and five neurological control patients were distributed across 10 international specialist neurochemical laboratories for analysis by a range of commercial and in-house neurofilament assays. The performance of all assays was evaluated for their ability to differentiate between the groups. The inter-assay coefficient of variation was calculated where appropriate from sample measurements performed across multiple laboratories using the same assay.Results:All assays could differentiate ALS patients from controls in CSF. Inter-assay coefficient of variation of analytical platforms performed across multiple laboratories varied between 6.5% and 41.9%.Conclusions:This study is encouraging for the growing momentum toward integration of neurofilament measurement into the specialized ALS clinic. It demonstrates the importance of 'round robin' studies necessary to ensure the analytical quality required for translation to the routine clinical setting. A standardized neurofilament probe is needed which can be used as international benchmark for analytical performance in ALS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Amyotrophic lateral sclerosis
- neurofilament
- biomarker
- cerebrospinal-fluid
- biomarker
- light
- csf
- validation
- onset
- chain
- serum
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gray, E.
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Oeckl, P.
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Amador, M. D. M.
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Andreasson, Ulf, ...
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An, J. Y.
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Blennow, Kaj, 19 ...
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show more...
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Bowser, R.
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De Schaepdryver, ...
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Heslegrave, A.
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Kuhle, J.
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Maceski, A.
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Koel-Simmelink, ...
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Lamari, F.
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Lombardi, V.
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Malaspina, A.
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Nilsson, Irina
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Poesen, K.
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Salachas, F.
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Steinacker, P.
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Teunissen, C. E.
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Van Damme, P.
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Zetterberg, Henr ...
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Ludolph, A.
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Jeromin, A.
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Turner, M. R.
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Otto, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Amyotrophic Late ...
- By the university
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University of Gothenburg