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Proteome profiling ...
Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease
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Bader, J. M. (author)
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Geyer, P. E. (author)
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Muller, J. B. (author)
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Strauss, M. T. (author)
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Koch, M. (author)
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Leypoldt, F. (author)
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Koertvelyessy, P. (author)
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Bittner, D. (author)
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Schipke, C. G. (author)
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Incesoy, E. I. (author)
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Peters, O. (author)
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Deigendesch, N. (author)
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Simons, M. (author)
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Jensen, M. K. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Mann, M. (author)
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(creator_code:org_t)
- 2020-06-02
- 2020
- English.
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In: Molecular Systems Biology. - : EMBO. - 1744-4292. ; 16:6
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Abstract
Subject headings
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- Neurodegenerative diseases are a growing burden, and there is an urgent need for better biomarkers for diagnosis, prognosis, and treatment efficacy. Structural and functional brain alterations are reflected in the protein composition of cerebrospinal fluid (CSF). Alzheimer's disease (AD) patients have higherCSFlevels of tau, but we lack knowledge of systems-wide changes ofCSFprotein levels that accompanyAD. Here, we present a highly reproducible mass spectrometry (MS)-based proteomics workflow for the in-depth analysis ofCSFfrom minimal sample amounts. From three independent studies (197 individuals), we characterize differences in proteins byADstatus (> 1,000 proteins,CV < 20%). Proteins with previous links to neurodegeneration such as tau,SOD1, andPARK7 differed most strongly byADstatus, providing strong positive controls for our approach.CSFproteome changes in Alzheimer's disease prove to be widespread and often correlated with tau concentrations. Our unbiased screen also reveals a consistent glycolytic signature across our cohorts and a recent study. Machine learning suggests clinical utility of this proteomic signature.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- cerebrospinal fluid
- mass spectrometry
- neurodegeneration
- proteomics
- mental-state-examination
- mass-spectrometry
- amyloid-pet
- csf
- plasma
- dementia
- tau
- quantification
- metaanalysis
- association
- Biochemistry & Molecular Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Bader, J. M.
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Geyer, P. E.
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Muller, J. B.
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Strauss, M. T.
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Koch, M.
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Leypoldt, F.
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show more...
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Koertvelyessy, P ...
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Bittner, D.
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Schipke, C. G.
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Incesoy, E. I.
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Peters, O.
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Deigendesch, N.
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Simons, M.
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Jensen, M. K.
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Zetterberg, Henr ...
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Mann, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Molecular System ...
- By the university
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University of Gothenburg