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Butyrate producing ...
Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways
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Pichler, M. J. (author)
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Yamada, C. (author)
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Shuoker, B. (author)
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Alvarez-Silva, C. (author)
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Gotoh, A. (author)
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Leth, M. L. (author)
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Schoof, E. (author)
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Katoh, T. (author)
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Sakanaka, M. (author)
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Katayama, T. (author)
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- Jin, Chunsheng (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Karlsson, Niclas G., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Arumugam, M. (author)
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Fushinobu, S. (author)
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Abou Hachem, M. (author)
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(creator_code:org_t)
- 2020-07-03
- 2020
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- The early life human gut microbiota exerts life-long health effects on the host, but the mechanisms underpinning its assembly remain elusive. Particularly, the early colonization of Clostridiales from the Roseburia-Eubacterium group, associated with protection from colorectal cancer, immune- and metabolic disorders is enigmatic. Here, we describe catabolic pathways that support the growth of Roseburia and Eubacterium members on distinct human milk oligosaccharides (HMOs). The HMO pathways, which include enzymes with a previously unknown structural fold and specificity, were upregulated together with additional glycan-utilization loci during growth on selected HMOs and in co-cultures with Akkermansia muciniphila on mucin, suggesting an additional role in enabling cross-feeding and access to mucin O-glycans. Analyses of 4599 Roseburia genomes underscored the preponderance and diversity of the HMO utilization loci within the genus. The catabolism of HMOs by butyrate-producing Clostridiales may contribute to the competitiveness of this group during the weaning-triggered maturation of the microbiota. The assembly and maturation of the early life microbiome has life-long effects on human health. Here, the authors combine omics, functional assays and structural analyses to characterize the catabolic pathways that support the growth of butyrate producing Clostridiales members from the Roseburia and Eubacterium, on distinct human milk oligosaccharides.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- human gut microbiome
- blood-group-a
- bacterial diversity
- protein-sequence
- breast-milk
- gen. nov.
- bifidobacterium
- health
- purification
- dynamics
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pichler, M. J.
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Yamada, C.
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Shuoker, B.
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Alvarez-Silva, C ...
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Gotoh, A.
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Leth, M. L.
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show more...
-
Schoof, E.
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Katoh, T.
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Sakanaka, M.
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Katayama, T.
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Jin, Chunsheng
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Karlsson, Niclas ...
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Arumugam, M.
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Fushinobu, S.
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Abou Hachem, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Nature Communica ...
- By the university
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University of Gothenburg