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Liver nucleotide bi...
Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes
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- Jain, Ruchi (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Ozgumus, T. (author)
- University of Bergen
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- Jensen, T. M. (author)
- Steno Diabetes Center Copenhagen,University of Southern Denmark
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- du Plessis, E. (author)
- University of Bergen
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- Keindl, M. (author)
- University of Bergen
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- Moller, C. L. (author)
- Steno Diabetes Center Copenhagen
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- Falhammar, H. (author)
- Karolinska Institutet
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- Nystrom, T. (author)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Catrina, S. B. (author)
- Karolinska Institutet,Karolinska Institute,Akademiskt specialistcentrum, Stockholm,Karolinska University Hospital
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- Jorneskog, G. (author)
- Karolinska Institute,Danderyd Hospital
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- Jessen, L. E. (author)
- Technical University of Denmark
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- Forsblom, C. (author)
- University of Helsinki,Helsinki University Central Hospital,Folkhälsan Research Center
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- Haukka, J. K. (author)
- Helsinki University of Technology,Helsinki University Central Hospital,Folkhälsan Research Center
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- Groop, P. H. (author)
- University of Helsinki,Folkhälsan Research Center,Monash University,Helsinki University Central Hospital
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- Rossing, P. (author)
- University of Copenhagen,Steno Diabetes Center Copenhagen
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),University of Helsinki
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- Eliasson, Mats (author)
- Umeå University,Umeå universitet,Avdelningen för medicin
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- Eliasson, Björn, 1959 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Brismar, K. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Al-Majdoub, Mahmoud (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
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- Nilsson, Peter M. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Taskinen, M. R. (author)
- University of Helsinki
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- Ferrannini, E. (author)
- CNR Institute of Clinical Physiology (IFC-CNR)
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- Spégel, Peter (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Berg, T. J. (author)
- Oslo university hospital,University of Oslo
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Bergen
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(creator_code:org_t)
- 2020-07-14
- 2020
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Abstract
Subject headings
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- Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma metabolite markers associated with freedom from vascular complications in people with very long duration of type 1 diabetes (T1D). Individuals with T1D, who despite having longer than 30 years of diabetes duration never developed major macro- or microvascular complications (non-progressors; NP) were compared with those who developed vascular complications within 25 years from diabetes onset (rapid progressors; RP) in the Scandinavian PROLONG (n = 385) and DIALONG (n = 71) cohorts. The DIALONG study also included 75 healthy controls. Plasma metabolites were measured using gas and/or liquid chromatography coupled to mass spectrometry. Lower hepatic fatty liver indices were significant common feature characterized NPs in both studies. Higher insulin sensitivity and residual beta-cell function (C-peptide) were also associated with NPs in PROLONG. Protection from diabetic complications was associated with lower levels of the glycolytic metabolite pyruvate and APOCIII in PROLONG, and with lower levels of thiamine monophosphate and erythritol, a cofactor and intermediate product in the pentose phosphate pathway as well as higher phenylalanine, glycine and serine in DIALONG. Furthermore, T1D individuals showed elevated levels of picolinic acid as compared to the healthy individuals. The present findings suggest a potential beneficial shunting of glycolytic substrates towards the pentose phosphate and one carbon metabolism pathways to promote nucleotide biosynthesis in the liver. These processes might be linked to higher insulin sensitivity and lower liver fat content, and might represent a mechanism for protection from vascular complications in individuals with long-term T1D.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Jain, Ruchi
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Ozgumus, T.
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Jensen, T. M.
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du Plessis, E.
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Keindl, M.
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Moller, C. L.
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show more...
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Falhammar, H.
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Nystrom, T.
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Catrina, S. B.
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Jorneskog, G.
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Jessen, L. E.
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Forsblom, C.
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Haukka, J. K.
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Groop, P. H.
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Rossing, P.
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Groop, Leif
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Eliasson, Mats
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Eliasson, Björn, ...
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Brismar, K.
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Al-Majdoub, Mahm ...
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Nilsson, Peter M ...
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Taskinen, M. R.
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Ferrannini, E.
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Spégel, Peter
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Berg, T. J.
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Lyssenko, Valeri ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Scientific Repor ...
- By the university
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University of Gothenburg
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Umeå University
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Lund University
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Karolinska Institutet