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Reliability of serum S100B measurement following mild traumatic brain injury: a comparison of assay measurements from two laboratories
- Iverson, G. L. (author)
- Posti, J. P. (author)
- Ohman, J. (author)
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- Luoto, T. M. (author)
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- (creator_code:org_t)
- 2020-08-03
- 2020
- English.
- In: Brain Injury. - : Informa UK Limited. - 0269-9052 .- 1362-301X. ; 34:9, s. 1237-1244
- Journal article (peer-reviewed)
Abstract
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- Objective There is enormous research and clinical interest in blood-based biomarkers of mild traumatic brain injury (MTBI) sustained in sports, daily life, or military service. We examined the reliability of a commercially available assay for S100B used on the same samples by two different laboratories separated by 2 years in time. Methods and Procedures A cohort of 163 adult patients (head CT-scanned, n = 110) with mild head injury were enrolled from the emergency department (ED). All had Glasgow Coma Scale scores of 14 or 15 in the ED (94.4% = 15). The mean time between injury and venous blood sampling was 2.9 h (SD = 1.4; Range = 0.5-6.0 h). Serum S100B was measured at two independent centers using the same high throughput clinical assay (Elecsys S100B (R); Roche Diagnostics). Results The Spearman correlation between the two assays in the total sample (N = 163) was r = 0.93. A Wilcoxson Signed Ranks test indicated that the median scores for the values differed (Z = 2,082,p< .001, Cohen's d = 0.151, small effect size). The values obtained from the two laboratories were very similar for identifying traumatic intracranial abnormalities (sensitivity = 80.1% versus 85.7%). Conclusions The serum S100B results measured using the same assay in different laboratories yielded highly correlated and clinically similar, but clearly not identical, results.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Traumatic brain injuries
- computed tomography
- psychometrics
- S100B
- protein
- emergency treatment
- neuron-specific enolase
- s-100 protein measurements
- blood-based
- biomarkers
- fluid biomarkers
- clinical utility
- elite players
- head-injury
- damage
- markers
- Neurosciences & Neurology
- Rehabilitation
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- ref (subject category)
- art (subject category)
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- Iverson, G. L.
- Posti, J. P.
- Ohman, J.
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- Luoto, T. M.
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- MEDICAL AND HEALTH SCIENCES
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- Brain Injury
- By the university
- University of Gothenburg
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