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A Short-Term Wester...
A Short-Term Western Diet Impairs Cholesterol Homeostasis and Key Players of Beta Amyloid Metabolism in Brain of Middle Aged Rats
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Spagnuolo, M. S. (author)
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Pallottini, V. (author)
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Mazzoli, A. (author)
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Iannotta, L. (author)
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Tonini, C. (author)
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Morone, B. (author)
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- Ståhlman, Marcus, 1975 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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Crescenzo, R. (author)
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Strazzullo, M. (author)
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Iossa, S. (author)
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Cigliano, L. (author)
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(creator_code:org_t)
- 2020-07-20
- 2020
- English.
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In: Molecular Nutrition & Food Research. - : Wiley. - 1613-4125 .- 1613-4133. ; 64:16
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Abstract
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- Scope Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can influence cerebral physiology, but the effect of western diets on brain cholesterol homeostasis, particularly at middle age, is unknown. Given the link between brain cholesterol alteration and beta amyloid production, the aim is to evaluate whether a diet rich in fat and fructose affects the protein network implicated in cholesterol synthesis and shuttling between glial cells and neurons, as well as crucial markers of beta amyloid metabolism. Methods and results Middle aged rats are fed a high fat-high fructose (HFF) or a control diet for 4 weeks. Inflammatory markers and cholesterol levels significantly increase in hippocampus of HFF rats. A higher activation of 3-hydroxy 3-methylglutaryl coenzyme-A reductase, coupled with lower levels of apolipoprotein E, LXR-beta, and lipoproteins receptors is measured in hippocampus from HFF rats. The alteration of critical players of cholesterol homeostasis is associated with increased level of amyloid precursor protein, presenilin 1, and nicastrin, and decreased level of insulin degrading enzyme. Conclusions Overall these data show that a western diet is associated with perturbation of cholesterol homeostasis in middle aged rats, mostly in hippocampus. This might trigger molecular events involved in the onset of neurodegenerative diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Spagnuolo, M. S.
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Pallottini, V.
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Mazzoli, A.
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Iannotta, L.
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Tonini, C.
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Morone, B.
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show more...
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Ståhlman, Marcus ...
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Crescenzo, R.
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Strazzullo, M.
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Iossa, S.
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Cigliano, L.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Molecular Nutrit ...
- By the university
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University of Gothenburg