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CD4(+) T cell proli...
CD4(+) T cell proliferative responses to PPD and CFP-10 associate with recent M. tuberculosis infection
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- Borgstrom, E. W. (author)
- Karolinska Institutet
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- Froberg, G. (author)
- Karolinska Institutet
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- Correia-Neves, M. (author)
- Karolinska Institutet
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- Atterfelt, Fredrik Bosdotter (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Bellbrant, J. (author)
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- Szulkin, R. (author)
- Karolinska Institutet
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- Chryssanthou, E. (author)
- Karolinska Institutet
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- Angeby, K. (author)
- Karolinska Institutet
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Tecleab, T. (author)
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Ruhwald, M. (author)
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Andersen, P. (author)
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- Kallenius, G. (author)
- Karolinska Institutet
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- Bruchfeld, J. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Tuberculosis. - : Elsevier BV. - 1472-9792 .- 1873-281X. ; 123
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Abstract
Subject headings
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- Interferon-gamma release assays cannot differentiate latent from active tuberculosis (TB), nor identify the recently infected with increased risk of active disease. The objective of this study was to identify biomarkers of recent infection following exposure to tuberculosis, to increase the positive predictive value for incipient TB. Contacts to patients with pulmonary TB were tested repeatedly with interferon-gamma release assays and flow-cytometry. Proliferative CD4(+) T cell responses to purified protein derivative (PPD) and 11 M. tuberculosis antigens were analysed. The individual probability of recent and remote infection was estimated using clinical data in a novel mathematical model and compared with CD4(+) responses in a prediction model. The most specific prediction of recent infection was high CD4(+) proliferative responses to CFP-10 and PPD and a low CD4(+) response to ESAT-6. CD4(+) proliferative responses to Rec85a, Rec85b and Rv1284 were also observed in recent infection, but did not reach significance in the prediction model. Conclusions: High CD4(+) proliferative responses to CFP-10 and PPD and a low response to ESAT-6 may be used as biomarkers to improve positive predictive values for recent LTBI and thus, increased risk of incipient TB. Rec85a, Rec85b and Rv1284 are also of interest to study further in this context.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Tuberculosis
- Diagnostics
- Interferon-gamma release assays
- Cellular
- immunity
- mycobacterium-tuberculosis
- whole-blood
- esat-6
- diagnosis
- immunity
- protein
- lymphoproliferation
- immunogenicity
- antigens
- level
- Immunology
- Microbiology
- Respiratory System
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Borgstrom, E. W.
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Froberg, G.
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Correia-Neves, M ...
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Atterfelt, Fredr ...
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Bellbrant, J.
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Szulkin, R.
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show more...
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Chryssanthou, E.
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Angeby, K.
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Tecleab, T.
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Ruhwald, M.
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Andersen, P.
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Kallenius, G.
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Bruchfeld, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Tuberculosis
- By the university
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University of Gothenburg
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Karolinska Institutet