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How much synthetic ...
How much synthetic oxytocin is infused during labour? A review and analysis of regimens used in 12 countries
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Daly, D. (author)
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Minnie, K. C. S. (author)
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Blignaut, A. (author)
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Blix, E. (author)
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Nilsen, A. B. V. (author)
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- Dencker, Anna, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences
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Beeckman, K. (author)
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Gross, M. M. (author)
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Pehlke-Milde, J. (author)
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Grylka-Baeschlin, S. (author)
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Koenig-Bachmann, M. (author)
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Clausen, J. A. (author)
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Hadjigeorgiou, E. (author)
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Morano, S. (author)
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Iannuzzi, L. (author)
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Baranowska, B. (author)
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Kiersnowska, I. (author)
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- Uvnäs-Moberg, Kerstin (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens miljö och hälsa (HMH),Department of Animal Environment and Health
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(creator_code:org_t)
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- 2020-07-28
- 2020
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 15:7
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Abstract
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- Objective To compare synthetic oxytocin infusion regimens used during labour, calculate the International Units (IU) escalation rate and total amount of IU infused over eight hours. Design Observational study Setting Twelve countries, eleven European and South Africa. Sample National, regional or institutional-level regimens on oxytocin for induction and augmentation labour Methods Data on oxytocin IU dose, infusion fluid amount, start dose, escalation rate and maximum dose were collected. Values for each regimen were converted to IU in 1000ml diluent. One IU corresponded to 1.67 mu g for doses provided in grams/micrograms. IU hourly dose increase rates were based on escalation frequency. Cumulative doses and total IU amount infused were calculated by adding the dose administered for each previous hour. Main Outcome Measures Oxytocin IU dose infused Results Data were obtained on 21 regimens used in 12 countries. Details on the start dose, escalation interval, escalation rate and maximum dose infused were available from 16 regimens. Starting rates varied from 0.06 IU/hour to 0.90 IU/hour, and the maximum dose rate varied from 0.90 IU/hour to 3.60 IU/hour. The total amount of IU oxytocin infused, estimated over eight hours, ranged from 2.38 IU to 27.00 IU, a variation of 24.62 IU and an 11-fold difference. Conclusion Current variations in oxytocin regimens for induction and augmentation of labour are inexplicable. It is crucial that the appropriate minimum infusion regimen is administered because synthetic oxytocin is a potentially harmful medication with serious consequences for women and babies when inappropriately used. Estimating the total amount of oxytocin IU received by labouring women, alongside the institution's mode of birth and neonatal outcomes, may deepen our understanding and be the way forward to identifying the optimal infusion regimen.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Keyword
- maternity care
- induction
- receptors
- hospitals
- health
- trends
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Daly, D.
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Minnie, K. C. S.
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Blignaut, A.
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Blix, E.
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Nilsen, A. B. V.
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Dencker, Anna, 1 ...
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show more...
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Beeckman, K.
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Gross, M. M.
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Pehlke-Milde, J.
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Grylka-Baeschlin ...
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Koenig-Bachmann, ...
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Clausen, J. A.
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Hadjigeorgiou, E ...
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Morano, S.
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Iannuzzi, L.
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Baranowska, B.
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Kiersnowska, I.
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Uvnäs-Moberg, Ke ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nursing
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PLoS ONE
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University of Gothenburg
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Swedish University of Agricultural Sciences