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Iodine deficiency in pregnant women in Sweden: a national cross-sectional study.

Manousou, Sofia, 1979 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
Andersson, Maria (author)
Eggertsen, Robert, 1948 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Hunziker, Sandra (author)
Hulthén, Lena, 1947 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Nyström, Helena Filipsson, 1966 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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 (creator_code:org_t)
2019-10-15
2020
English.
In: European journal of nutrition. - : Springer Science and Business Media LLC. - 1436-6215 .- 1436-6207. ; 59:6, s. 2535-2545
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Voluntary salt iodization at 50mg/kg salt ensures adequate iodine nutrition in Swedish school-aged children, but iodine status in pregnant women is uncertain.We conducted a cross-sectional national study of 743 pregnant women, at median gestational age of 23weeks (IQR 9, 38), recruited from maternal health care centers. We measured: urinary iodine concentration (UIC) and urinary creatinine concentration in spot urine samples; thyroglobulin (Tg), thyroid-stimulating hormone (TSH), and total thyroxine (tT4) on dried blood spots (DBS); and thyreoperoxidase antibodies in serum samples. Data on dietary supplement use were obtained, and women were classified as supplement users (consuming multivitamins containing≥150µg iodine/day) and non-supplement users (no supplements or<150µg iodine/day from supplements).Overall median UIC [bootstrapped 95% confidence interval (CI)] was 101µg/L (95, 108; n=737): 149µg/L (132, 164) in supplement users (n=253) and 85µg/L (79, 92) in non-supplement users (n=440) (p<0.001). Overall geometric mean DBS-Tg (95% CI) was 22.1μg/L (20.8, 23.5; n=675) and the prevalence of elevated DBS-Tg was 19%. DBS-Tg was lower in supplement users (n=229) than in non-supplement users (n=405) (19.1 vs 24.4μg/L, p<0.001). DBS-TSH, DBS-tT4, and S-TPOab positivity did not differ between the two groups.Pregnant women in Sweden have inadequate iodine nutrition. Women not taking iodine supplements containing≥150µg iodine/day are affected by mild iodine deficiency and are at higher risk for increased thyroid activity, while maintaining euthyroidism. Iodine intake should be improved in women both before and after conception by promotion of iodized salt instead of non-iodized salt. We urge regular monitoring of iodine status in the general Swedish population, as well as in risk groups.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Allmänmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- General Practice (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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