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Human Immune System...
Human Immune System Variation during 1 Year
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- Lakshmikanth, T. (author)
- Karolinska Institutet
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- Muhammad, S. A. (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Karolinska, Solna, Sweden.
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- Olin, A. (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Karolinska, Solna, Sweden.
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- Chen, Y. (author)
- Karolinska Institutet
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- Mikes, J. (author)
- Karolinska Institutet
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- Fagerberg, Linn (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Gummesson, Anders, 1973 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Physiol, Gothenburg, Sweden.
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- Bergström, Göran, 1964 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Physiol, Gothenburg, Sweden.
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Brodin, P. (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Karolinska, Solna, Sweden (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 32:3
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Abstract
Subject headings
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- The human immune system varies extensively between individuals, but variation within individuals over time has not been well characterized. Systems-level analyses allow for simultaneous quantification of many interacting immune system components and the inference of global regulatory principles. Here, we present a longitudinal, systems-level analysis in 99 healthy adults 50 to 65 years of age and sampled every third month for 1 year. We describe the structure of interindividual variation and characterize extreme phenotypes along a principal cum. From coordinated measurement fluctuations, we infer relationships between 115 immune cell populations and 750 plasma proteins constituting the blood immune system. While most individuals have stable immune systems, the degree of longitudinal variability is an individual feature. The most variable individuals, in the absence of overt infections, exhibited differences in markers of metabolic health suggestive of a possible link between metabolic and immunologic homeostatic regulation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- age
- cells
- vaccination
- responses
- driven
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lakshmikanth, T.
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Muhammad, S. A.
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Olin, A.
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Chen, Y.
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Mikes, J.
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Fagerberg, Linn
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Gummesson, Ander ...
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Bergström, Göran ...
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Uhlén, Mathias
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Brodin, P.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Cell Reports
- By the university
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University of Gothenburg
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Royal Institute of Technology
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Karolinska Institutet