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Genetic identificat...
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Bryois, J.Karolinska Institutet
(author)
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-04-27
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Springer Science and Business Media LLC,2020
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/296136
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https://gup.ub.gu.se/publication/296136URI
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https://doi.org/10.1038/s41588-020-0610-9DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143572790URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
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Skene, N. G.
(author)
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Hansen, T. F.
(author)
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Kogelman, L. J. A.
(author)
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Watson, H. J.
(author)
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Liu, Z.
(author)
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Adan, Roger A. H.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xadaro
(author)
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Alfredsson, L.
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Ando, T.
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Andreassen, O.
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Baker, J.
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Bergen, A.
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Berrettini, W.
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Birgegård, A.
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Boden, J.
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Boehm, I.
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Boni, C.
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Boraska Perica, V.
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Brandt, H.
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Breen, G.
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Bryois, J.
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Buehren, K.
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Bulik, C.
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Burghardt, R.
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Cassina, M.
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Cichon, S.
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Clementi, M.
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Coleman, J.
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Cone, R.
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Courtet, P.
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Crawford, S.
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Crow, S.
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Crowley, J.
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Danner, U.
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Davis, O.
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de Zwaan, M.
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DeSocio, J.
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Dick, D.
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Dikeos, D.
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Dina, C.
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Dmitrzak-Weglarz, M.
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Docampo Martinez, E.
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Duncan, L.
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Egberts, K.
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Ehrlich, S.
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Escaramís, G.
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Esko, T.
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Estivill, X.
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Farmer, A.
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Favaro, A.
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Fernández-Aranda, F.
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Fichter, M.
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Fischer, K.
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Föcker, M.
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Foretova, L.
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Forstner, A.
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Forzan, M.
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Franklin, C.
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Gallinger, S.
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Gaspar, H.
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Giegling, I.
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Giuranna, J.
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Giusti-Rodríquez, P.
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Gonidakis, F.
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Gordon, S.
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Gorwood, P.
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Gratacos Mayora, M.
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Grove, J.
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Guillaume, S.
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Guo, Y.
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Hakonarson, H.
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Halmi, K.
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Hanscombe, K.
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Hatzikotoulas, K.
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Hauser, J.
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Hebebrand, J.
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Helder, S.
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Henders, A.
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Herms, S.
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Herpertz-Dahlmann, B.
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Herzog, W.
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Hinney, A.
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Horwood, L. J.
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Hübel, C.
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Huckins, L.
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Hudson, J.
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Imgart, H.
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Inoko, H.
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Janout, V.
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Jiménez-Murcia, S.
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Johnson, C.
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Jordan, J.
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Julià, A.
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Juréus, A.
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Kalsi, G.
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Kaminská, D.
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Kaplan, A.
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Kaprio, J.
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Karhunen, L.
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Karwautz, A.
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Kas, M.
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Kaye, W.
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Kennedy, J.
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Kennedy, M.
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Keski-Rahkonen, A.
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Kiezebrink, K.
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Kim, Y. R.
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Kirk, K.
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Klareskog, L.
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Klump, K.
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Knudsen, G. P.
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La Via, M.
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Landén, M.
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Larsen, J.
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Le Hellard, S.
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Leppä, V.
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Levitan, R.
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Li, D.
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Lichtenstein, P.
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Lilenfeld, L.
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Lin, B. D.
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Lissowska, J.
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Luykx, J.
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Magistretti, P.
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Maj, M.
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Mannik, K.
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Marsal, S.
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Marshall, C.
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Martin, N.
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Mattheisen, M.
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Mattingsdal, M.
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McDevitt, S.
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McGuffin, P.
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Medland, S.
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Metspalu, A.
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Meulenbelt, I.
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Micali, N.
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Mitchell, J.
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Mitchell, K.
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Monteleone, P.
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Monteleone, A. M.
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Montgomery, G.
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Mortensen, P. B.
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Munn-Chernoff, M.
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Nacmias, B.
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Navratilova, M.
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Norring, C.
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Ntalla, I.
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Olsen, C.
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Ophoff, R.
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O’Toole, J.
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Padyukov, L.
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Palotie, A.
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Pantel, J.
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Papezova, H.
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Parker, R.
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Pearson, J.
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Pedersen, N.
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Petersen, L.
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Pinto, D.
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Purves, K.
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Rabionet, R.
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Raevuori, A.
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Ramoz, N.
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Reichborn-Kjennerud, T.
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Ricca, V.
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Ripatti, S.
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Ripke, S.
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Ritschel, F.
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Roberts, M.
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Rotondo, A.
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Rujescu, D.
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Rybakowski, F.
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Santonastaso, P.
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Scherag, A.
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Scherer, S.
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Schmidt, U.
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Schork, N.
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Schosser, A.
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Seitz, J.
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Slachtova, L.
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Slagboom, P. E.
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Slof-Op ‘t Landt, M.
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Slopien, A.
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Sorbi, S.
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Strober, M.
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Stuber, G.
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Sullivan, P.
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Świątkowska, B.
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Szatkiewicz, J.
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Tachmazidou, I.
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Tenconi, E.
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Thornton, L.
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Tortorella, A.
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Tozzi, F.
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Treasure, J.
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Tsitsika, A.
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Tyszkiewicz-Nwafor, M.
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Tziouvas, K.
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van Elburg, A.
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van Furth, E.
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Wade, T.
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Wagner, G.
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Walton, E.
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Watson, H.
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Werge, T.
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Whiteman, D.
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Widen, E.
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Woodside, D. B.
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Yao, S.
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Yilmaz, Z.
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Zeggini, E.
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Zerwas, S.
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Zipfel, S.
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Anttila, V.
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Artto, V.
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Belin, A. C.
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de Boer, I.
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Boomsma, D. I.
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Børte, S.
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Chasman, D. I.
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Cherkas, L.
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Christensen, A. F.
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Cormand, B.
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Cuenca-Leon, E.
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Davey-Smith, G.
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Dichgans, M.
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van Duijn, C.
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Esko, T.
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Esserlind, A. L.
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Ferrari, M.
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Frants, R. R.
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Freilinger, T.
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Furlotte, N.
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Gormley, P.
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Griffiths, L.
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Hamalainen, E.
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Hansen, T. F.
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Hiekkala, M.
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Ikram, M. A.
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Ingason, A.
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Järvelin, M. R.
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Kajanne, R.
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Kallela, M.
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Kaprio, J.
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Kaunisto, M.
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Kogelman, L. J. A.
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Kubisch, C.
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Kurki, M.
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Kurth, T.
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Launer, L.
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Lehtimaki, T.
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Lessel, D.
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Ligthart, L.
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Litterman, N.
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Maagdenberg, A.
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Macaya, A.
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Malik, R.
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Mangino, M.
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McMahon, G.
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Muller-Myhsok, B.
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Neale, B. M.
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Northover, C.
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Nyholt, D. R.
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Olesen, J.
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Palotie, A.
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Palta, P.
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Pedersen, L.
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Pedersen, N.
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Posthuma, D.
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Pozo-Rosich, P.
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Pressman, A.
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Raitakari, O.
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Schürks, M.
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Sintas, C.
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Stefansson, K.
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Stefansson, H.
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Steinberg, S.
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Strachan, D.
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Terwindt, G.
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Vila-Pueyo, M.
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Wessman, M.
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Winsvold, B. S.
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Zhao, H.
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Zwart, J. A.
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Agee, M.
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Alipanahi, B.
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Auton, A.
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Bell, R.
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Bryc, K.
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Elson, S.
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Fontanillas, P.
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Furlotte, N.
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Heilbron, K.
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Hinds, D.
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Huber, K.
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Kleinman, A.
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Litterman, N.
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McCreight, J.
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McIntyre, M.
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Mountain, J.
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Noblin, E.
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Northover, C.
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Pitts, S.
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Sathirapongsasuti, J.
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Sazonova, O.
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Shelton, J.
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Shringarpure, S.
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Tian, C.
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Tung, J.
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Vacic, V.
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Wilson, C.
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Brueggeman, L.
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Breen, G.
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Bulik, C. M.
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Arenas, E.
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Hjerling-Leffler, J.
(author)
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Sullivan, P. F.
(author)
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC52:5, s. 482-4931061-40361546-1718
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Zeggini, E.
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Zerwas, S.
-
Zipfel, S.
-
Anttila, V.
-
Artto, V.
-
Belin, A. C.
-
de Boer, I.
-
Boomsma, D. I.
-
Børte, S.
-
Chasman, D. I.
-
Cherkas, L.
-
Christensen, A. ...
-
Cormand, B.
-
Cuenca-Leon, E.
-
Davey-Smith, G.
-
Dichgans, M.
-
van Duijn, C.
-
Esserlind, A. L.
-
Ferrari, M.
-
Frants, R. R.
-
Freilinger, T.
-
Furlotte, N.
-
Gormley, P.
-
Griffiths, L.
-
Hamalainen, E.
-
Hiekkala, M.
-
Ikram, M. A.
-
Ingason, A.
-
Järvelin, M. R.
-
Kajanne, R.
-
Kallela, M.
-
Kaunisto, M.
-
Kubisch, C.
-
Kurki, M.
-
Kurth, T.
-
Launer, L.
-
Lehtimaki, T.
-
Lessel, D.
-
Ligthart, L.
-
Litterman, N.
-
Maagdenberg, A.
-
Macaya, A.
-
Malik, R.
-
Mangino, M.
-
McMahon, G.
-
Muller-Myhsok, B ...
-
Neale, B. M.
-
Northover, C.
-
Nyholt, D. R.
-
Olesen, J.
-
Palta, P.
-
Pedersen, L.
-
Posthuma, D.
-
Pozo-Rosich, P.
-
Pressman, A.
-
Raitakari, O.
-
Schürks, M.
-
Sintas, C.
-
Stefansson, K.
-
Stefansson, H.
-
Steinberg, S.
-
Strachan, D.
-
Terwindt, G.
-
Vila-Pueyo, M.
-
Wessman, M.
-
Winsvold, B. S.
-
Zhao, H.
-
Zwart, J. A.
-
Agee, M.
-
Alipanahi, B.
-
Auton, A.
-
Bell, R.
-
Bryc, K.
-
Elson, S.
-
Fontanillas, P.
-
Heilbron, K.
-
Hinds, D.
-
Huber, K.
-
Kleinman, A.
-
McCreight, J.
-
McIntyre, M.
-
Mountain, J.
-
Noblin, E.
-
Pitts, S.
-
Sathirapongsasut ...
-
Sazonova, O.
-
Shelton, J.
-
Shringarpure, S.
-
Tian, C.
-
Tung, J.
-
Vacic, V.
-
Wilson, C.
-
Brueggeman, L.
-
Bulik, C. M.
-
Arenas, E.
-
Hjerling-Leffler ...
-
Sullivan, P. F.
-
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Genetics
- By the university
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University of Gothenburg
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Karolinska Institutet