The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits

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The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits

Hedenqvist, Patricia (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences

Trbakovic, Amela (author): Uppsala universitet,Plastikkirurgi

Mellgren, Torbjörn, 1986- (author): Uppsala universitet,Polymerkemi

Öhman Mägi, Caroline (author): Uppsala universitet,Tillämpad materialvetenskap

Hammarström Johansson, Petra, 1967 (author): Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 2,Institute of Odontology, Section 2

Manell, Elin (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences

Ekman, Stina (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences

Ley, Cecilia (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health

Jensen Waern, Marianne (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences

Thor, Andreas (author): Uppsala universitet,Plastikkirurgi,Oral & Maxillofacial Surgery

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2020-05-21
2020
English.
In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 15:5

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Journal article (peer-reviewed)

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In animal studies on bone healing, the effect of housing space and physical activity are seldom taken into account. Bone formation was evaluated in New Zealand White rabbits (mean ± SEM BW: 3.9 ± 0.11 kg) with a critical bone defect after 12 weeks of rehabilitation in pair-housing in 3 m2 large floor pens (Floor, n = 10) or standard single housing in 0.43 m2 cages (Cage, n = 10). In the randomised full-factorial study, a bone replica of calcium phosphate cement (CPC, n = 10) or autologous bone (AB, n = 10) was implanted in the unilateral 20 mm radius defect. Post-mortem, the oxidative capacity was measured by citrate synthase (CS) activity in M. quadriceps and the defect filling volume and density evaluated by microcomputer tomography (μ-CT). Histology sections were evaluated by subjective scoring and histomorphometry. Fourteen rabbits remained until the end of the study. Group Floor (n = 7; 3 CPC + 4 AB) had a higher CS activity and a larger bone defect filling volume and lower density by μ-CT measurements than group Cage (n = 7; 3 CPC + 4 AB). Three out of four rabbits in AB-Floor presented fusion of the defect with reorganisation of trabecular bone, whereas three of four in AB-Cage showed areas of incomplete healing. Floor rabbits had a higher score of bony fusion between the radius and ulna than Cage rabbits. There were no differences between groups in histomorphometry. The study found that a larger housing space increased physical activity and promoted bone formation. © 2020 Hedenqvist et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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By the author/editor: Hedenqvist, Patr ...; Trbakovic, Amela; Mellgren, Torbjö ...; Öhman Mägi, Caro ...; Hammarström Joha ...; Manell, Elin; show more...; Ekman, Stina; Ley, Cecilia; Jensen Waern, Ma ...; Thor, Andreas; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Animal and Dairy ...; and Animal and Dairy ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

Articles in the publication: Plos One

By the university: University of Gothenburg; Swedish University of Agricultural Sciences; Uppsala University

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The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits

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