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Analysis of copy nu...
Analysis of copy number alterations reveals the lncRNA ALAL-1 as a regulator of lung cancer immune evasion
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Athie, Alejandro (author)
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Marchese, Francesco P (author)
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González, Jovanna (author)
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Lozano, Teresa (author)
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Raimondi, Ivan (author)
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- Juvvuna, Prasanna Kumar (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Abad, Amaya (author)
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Marin-Bejar, Oskar (author)
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Serizay, Jacques (author)
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Martínez, Dannys (author)
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Ajona, Daniel (author)
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Pajares, Maria Jose (author)
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Sandoval, Juan (author)
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Montuenga, Luis M (author)
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- Kanduri, Chandrasekhar, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Lasarte, Juan J (author)
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Huarte, Maite (author)
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(creator_code:org_t)
- 2020-08-27
- 2020
- English.
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In: The Journal of cell biology. - : Rockefeller University Press. - 1540-8140 .- 0021-9525. ; 219:9
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https://rupress.org/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Cancer is characterized by genomic instability leading to deletion or amplification of oncogenes or tumor suppressors. However, most of the altered regions are devoid of known cancer drivers. Here, we identify lncRNAs frequently lost or amplified in cancer. Among them, we found amplified lncRNA associated with lung cancer-1 (ALAL-1) as frequently amplified in lung adenocarcinomas. ALAL-1 is also overexpressed in additional tumor types, such as lung squamous carcinoma. The RNA product of ALAL-1 is able to promote the proliferation and tumorigenicity of lung cancer cells. ALAL-1 is a TNFα- and NF-κB-induced cytoplasmic lncRNA that specifically interacts with SART3, regulating the subcellular localization of the protein deubiquitinase USP4 and, in turn, its function in the cell. Interestingly, ALAL-1 expression inversely correlates with the immune infiltration of lung squamous tumors, while tumors with ALAL-1 amplification show lower infiltration of several types of immune cells. We have thus unveiled a pro-oncogenic lncRNA that mediates cancer immune evasion, pointing to a new target for immune potentiation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Long noncoding RNA
- Lung cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Athie, Alejandro
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Marchese, France ...
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González, Jovann ...
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Lozano, Teresa
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Raimondi, Ivan
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Juvvuna, Prasann ...
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show more...
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Abad, Amaya
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Marin-Bejar, Osk ...
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Serizay, Jacques
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Martínez, Dannys
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Ajona, Daniel
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Pajares, Maria J ...
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Sandoval, Juan
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Montuenga, Luis ...
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Kanduri, Chandra ...
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Lasarte, Juan J
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Huarte, Maite
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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The Journal of c ...
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University of Gothenburg