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Patient reported ex...
Patient reported exposure to smoking and alcohol abuse are associated with pain and other complications in patients with chronic pancreatitis
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Tjora, E. (author)
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Dimcevski, G. (author)
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- Haas, S. L. (author)
- Karolinska Institutet
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Erchinger, F. (author)
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Vujasinovic, M. (author)
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- Lohr, M. (author)
- Karolinska Institutet
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Nojgaard, C. (author)
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Novovic, S. (author)
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Zalite, I. O. (author)
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Pukitis, A. (author)
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Hauge, T. (author)
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Waage, A. (author)
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Roug, S. (author)
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Kalaitzakis, E. (author)
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- Lindkvist, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Olesen, S. S. (author)
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Engjom, T. (author)
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Scandinavian Baltic, Pancreatic (author)
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Pancreatology. - : Elsevier BV. - 1424-3903. ; 20:5, s. 844-851
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Abstract
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- Background/objectives: Smoking and alcohol abuse are established risk factors for chronic pancreatitis (CP). Few studies have examined how exposure to smoking and alcohol abuse act as risk factors for complications in CP. Our aim was to examine associations between patient reported exposure to smoking and alcohol abuse and complications in CP in a large cohort of patients from the Scandinavian and Baltic countries. Methods: We retrieved data on demographics, CP related complications and patients' histories of exposure to smoking and alcohol abuse from the Scandinavian Baltic Pancreatic Club database. Associations were investigated by univariate and multivariate logistic regression analyses. Results are presented as odds ratios (OR) with 95% confidence intervals. Results: A complete history of smoking and alcohol exposure was available for 932 patients. In multivariate regression analyses, the presence of pain and exocrine pancreatic insufficiency were both significantly associated with history of smoking (OR 1.94 (1.40-2.68), p < 0.001 and OR 1.89 (1.36-2.62), p < 0.001, respectively) and alcohol abuse (OR 1.66 (1.21-2.26), p = 0.001 and 1.55 (1.14-2.11), p = 0.005, respectively). Smoking was associated with calcifications (OR 2.89 (2.09-3.96), p < 0.001), moderate to severe ductal changes (OR 1.42 (1.05-1.92), p = 0.02), and underweight (OR 4.73 (2.23-10.02), p < 0.001). History of alcohol abuse was associated with pseudocysts (OR 1.38 (1.00-1.90) p = 0.05) and diabetes mellitus (OR 1.44 (1.03-2.01), p = 0.03). There were significantly increased odds-ratios for several complications with increasing exposure to smoking and alcohol abuse. Conclusion: Smoking and alcohol abuse are both independently associated with development of complications in patients with CP. There seems to be a dose-dependent relationship between smoking and alcohol abuse and complications in CP. (c) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Chronic pancreatitis
- Smoking
- Alcohol abuse
- Complications
- Epidemiology
- cigarette-smoking
- natural-history
- risk-factor
- nicotine
- therapy
- men
- Gastroenterology & Hepatology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tjora, E.
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Dimcevski, G.
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Haas, S. L.
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Erchinger, F.
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Vujasinovic, M.
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Lohr, M.
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show more...
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Nojgaard, C.
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Novovic, S.
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Zalite, I. O.
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Pukitis, A.
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Hauge, T.
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Waage, A.
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Roug, S.
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Kalaitzakis, E.
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Lindkvist, Björn
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Olesen, S. S.
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Engjom, T.
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Scandinavian Bal ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Pancreatology
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Pancreatology : ...
- By the university
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University of Gothenburg
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Karolinska Institutet