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Early prediction of...
Early prediction of adverse outcomes in infants with acute bilirubin encephalopathy
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Kang, W. Q. (author)
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Yuan, X. (author)
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Zhang, Y. D. (author)
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- Song, Juan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Xu, F. L. (author)
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Liu, D. P. (author)
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Li, R. (author)
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Xu, B. L. (author)
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Li, W. (author)
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Cheng, Y. C. (author)
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- Zhu, Changlian, 1964 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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(creator_code:org_t)
- 2020-06-04
- 2020
- English.
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In: Annals of Clinical and Translational Neurology. - : Wiley. - 2328-9503. ; 7:7, s. 1141-1147
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Abstract
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- Objective Acute bilirubin encephalopathy (ABE) remains one of the important causes of neonatal mortality and child disability, early identification, and intervention which could improve outcomes. The purpose of this study was to evaluate early predictors of adverse outcomes in infants with ABE. Methods Newborns of gestational age >= 35 weeks and diagnosed with ABE were included in the study. Bilirubin-induced neurological dysfunction (BIND) score, total serum bilirubin (TSB) peak value, and serum albumin levels were determined. Adverse outcomes were defined as death or survival with auditory dysfunction and/or cerebral palsy. Results Eighty-two infants were eligible for recruitment in the study. The outcome data from 76 ABE infants (92%) were used for analysis, of which 25 infants got adverse outcomes and 51 live a normal life. Univariate analysis for BIND score, TSB peak value, bilirubin-albumin ratio (B/A), albumin level, abnormal AABR, and neonatal sepsis was performed to elucidate the association with adverse outcomes. Bivariate logistic regression analysis showed B/A (OR 10.48, 95%CI: 1.55-70.81, P = 0.02) and BIND score (OR 3.68, 95%CI: 1.39-9.72, P = 0.01) were correlated with adverse outcomes. ROC curve analysis showed that B/A (>= 8.9 mg/g), BIND score (>= 6) could predict adverse outcomes of ABE separately; B/A in conjunction with BIND score could increase prediction sensitivity to 100%. Interpretation Both B/A and BIND score can be used to predict adverse outcomes of ABE, and the combination of the two parameters can increase prediction sensitivity significantly.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- unbound bilirubin
- serum bilirubin
- management
- ratio
- kernicterus
- age
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kang, W. Q.
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Yuan, X.
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Zhang, Y. D.
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Song, Juan
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Xu, F. L.
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Liu, D. P.
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show more...
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Li, R.
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Xu, B. L.
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Li, W.
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Cheng, Y. C.
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Zhu, Changlian, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Annals of Clinic ...
- By the university
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University of Gothenburg
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Karolinska Institutet