Patch testing with purified and oxidized citronellol

Hagvall, Lina,1978Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology (author)

Background Citronellol is a commonly used fragrance terpene included in fragrance mix II. As with many other fragrance terpenes, citronellol is susceptible to autoxidation. Citronellol hydroperoxides are formed in large amounts and are the only oxidation products identified as sensitizers in oxidized citronellol. Aim To compare frequencies of contact allergy to purified and oxidized citronellol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series, oxidized linalool, and oxidized limonene. Methods A total of 658 dermatitis patients were patch tested with purified and oxidized citronellol at 2.0%, 4.0%, 6.0%, and 1.0%, 2.0%, 4.0%, 6.0% petrolatum, respectively. The irritant properties of purified and oxidized citronellol were studied before patch testing. Results Few irritant reactions were observed in the pretest. Purified citronellol detected positive reactions in 0.15%-0.31% of patients, while oxidized citronellol detected positive reactions in 0.61%-4.5%. Among patients reacting to oxidized citronellol, 34%-50% showed concomitant reactions to fragrance markers of the baseline series and 75%-91% to oxidized linalool or oxidized limonene. Conclusion Oxidized citronellol detects more cases of contact allergy than purified citronellol, and these cases are not all detected using fragrance mix II. Patch testing with oxidized citronellol will add to the tools in the diagnosis of fragrance allergy.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
allergic contact dermatitis
citronellol
fragrance mix II
fragrances
hydroperoxides
patch test
terpenes
contact allergens
d-limonene
oxidation-products
cosmetic products
skin irritation
air oxidation
hydroperoxides
linalool
sensitization
quantification
Allergy
Dermatology

Rudbäck, Johanna,1984Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institutionen för kemi och molekylärbiologi,Institute of Clinical Sciences, Department of Dermatology and Venereology,Department of Chemistry and Molecular Biology(Swepub:gu)xnjohp (author)
Bråred Christensson, Johanna,1965Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Department of Chemistry and Molecular Biology,Institute of Clinical Sciences, Department of Dermatology and Venereology(Swepub:gu)xbrarj (author)
Karlberg, Ann-Therese,1947Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xkaann (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi (creator_code:org_t)

By the author/editor: Hagvall, Lina, 1 ...; Rudbäck, Johanna ...; Bråred Christens ...; Karlberg, Ann-Th ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

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