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Characteristics and...
Characteristics and outcome of a first acute myocardial infarction in patients with ankylosing spondylitis
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- Södergren, Anna, 1977- (author)
- Umeå universitet,Reumatologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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- Askling, J. (author)
- Karolinska Institutet
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- Bengtsson, Karin, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Forsblad d'Elia, Helena, 1961 (author)
- Umeå universitet,Reumatologi
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- Jernberg, T. (author)
- Karolinska Institutet
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- Lindström, Ulf (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Ljung, Lotta, 1964- (author)
- Karolinska Institutet,Umeå universitet,Reumatologi,Clinical Epidemiology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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- Mantel, A. (author)
- Karolinska Institutet
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- Jacobsson, Lennart T. H., 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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(creator_code:org_t)
- 2020-08-26
- 2021
- English.
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In: Clinical Rheumatology. - : Springer Science and Business Media LLC. - 0770-3198 .- 1434-9949. ; 40, s. 1321-1329
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objectives To study clinical characteristics, mortality, and secondary prevention, after a first incident acute myocardial infarction (AMI) in patients with ankylosing spondylitis (AS) compared with the general population. Methods In total, 292 subjects with AS and a first AMI between Jan 2006 and Dec 2014 were identified using the Swedish national patient register. Each subject was matched with up to 5 general population comparators per AS-patient (n = 1276). Follow-up started at the date of admission for AMI and extended until death or 365 days of follow-up. Cox regression was used to assess mortality in two time intervals: days 0-30 and days 31-365. For a subgroup with available data, clinical presentation at admission, course, treatment for AMI, and secondary prevention were compared. Results During the 365-day follow-up, 56/292 (19%) AS patients and 184/1276 (14%) comparators died. There were no difference in mortality due to cardiovascular-related causes, although the overall mortality day 31-365 was increased among patients with AS compared with comparators (HR [95% CI] = 2.0 [1.3;3.0]). At admission, AS patients had a higher prevalence of cardiovascular comorbidities compared with comparators. At discharge, patients with AS were less often prescribed lipid-lowering drugs and non-aspirin antiplatelet therapy. Conclusions Patients with AS tend to have a higher comorbidity burden at admission for first AMI. The mortality after a first AMI due to cardiovascular-related causes does not seem to be elevated, despite an increased overall mortality during days 31-365 among patients with AS compared with the general population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Acute myocardial infarction
- Ankylosing spondylitis
- Cardiovascular
- disease
- Mortality
- acute coronary syndrome
- population
- mortality
- risk
- Rheumatology
- Acute myocardial infarction
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Södergren, Anna, ...
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Askling, J.
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Bengtsson, Karin ...
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Forsblad d'Elia, ...
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Jernberg, T.
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Lindström, Ulf
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Ljung, Lotta, 19 ...
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Mantel, A.
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Jacobsson, Lenna ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Clinical Rheumat ...
- By the university
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University of Gothenburg
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Umeå University
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Karolinska Institutet