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Pulmonary Hemodynam...
Pulmonary Hemodynamics and Outcome in a Large Cohort of Patients with Sinus Venosus Septal Defect
- Article/chapterEnglish2020
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Computers, Materials and Continua (Tech Science Press),2020
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LIBRIS-ID:oai:gup.ub.gu.se/296731
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https://gup.ub.gu.se/publication/296731URI
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https://doi.org/10.32604/chd.2020.011512DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Left-to-right shunt in sinus venosus septal defect (SVSD) may affect resistive (pulmonary vascular resistance-PVR) and elastic (pulmonary artery compliance-PAC) pulmonary artery properties. This study aimed at evaluating (1) impact of age, (2) pulmonary hemodynamics, and (3) outcome in a large cohort of SVSD patients. Methods: This study included 136 patients with SVSD (median age at diagnosis 14 (IQR 5-48) years, 47% male) of which 87 underwent catheterization. Pressures were measured and cardiac output was evaluated using the Fick principle at diagnosis. PVR, PAC and their product (RC time) were calculated. Results: Surgical repair was performed in 128 (94%) at a median age of 13 (IQR 5- 43) years. During a median follow-up time of 31 (IQR 17-55) years, 12 (9%) patients died, 13 (10%) developed heart failure, 4 (3%) Eisenmenger syndrome, 19 (14%) atrial arrhythmia, 6 (4%) sick sinus syndrome and 7 (5%) required pacemaker implantation In those who underwent catheterization, median shunt ratio was 2.5 (IQR 2.0-2.9). Thirty (34%) had mean PA pressure >= 25 mmHg. PVR indexed, PAC indexed, and RC time was 3.5 (IQR 2.4-7.5) WU.m(2) , 1.8 (IQR 1.3-2.5) mL/mmHg.m(2) and 0.39 (0.26-0.53) sec with an inverse hyperbolic relationship between PVR and PAC. Mean PA pressure (P < 0.0001); wedge pressure (P = 0.001), PVR indexed (P = 0.002) and PAC indexed (P = 0.002) changed significantly with age at diagnosis, but shunt ratio did not. Conclusion: SVSD has good long-term outcome, albeit with late morbidities. Thirty-four percent has mean PA pressure >= 25 mmHg, but Eisenmenger syndrome is rare (3%). PVR and PAC are inversely related and change significantly with older age.
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Santens, B.
(author)
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Troost, E.
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De Meester, P.
(author)
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Roggen, L.
(author)
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Rega, F.
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Meyns, B.
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Cools, B.
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Gewillig, M.
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Moons, Philip,1968Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences(Swepub:gu)xmooph
(author)
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Meier, L.
(author)
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Budts, W.
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Van de Bruaene, A.
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Göteborgs universitetInstitutionen för vårdvetenskap och hälsa
(creator_code:org_t)
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In:Congenital Heart Disease: Computers, Materials and Continua (Tech Science Press)15:2, s. 69-781747-079X
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van Dessel, L.
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Santens, B.
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Troost, E.
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De Meester, P.
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Roggen, L.
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Rega, F.
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Meyns, B.
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Cools, B.
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Gewillig, M.
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Moons, Philip, 1 ...
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Meier, L.
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Budts, W.
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Van de Bruaene, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Congenital Heart ...
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University of Gothenburg