SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:gup.ub.gu.se/296731"
 

Search: onr:"swepub:oai:gup.ub.gu.se/296731" > Pulmonary Hemodynam...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • van Dessel, L. (author)

Pulmonary Hemodynamics and Outcome in a Large Cohort of Patients with Sinus Venosus Septal Defect

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Computers, Materials and Continua (Tech Science Press),2020

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/296731
  • https://gup.ub.gu.se/publication/296731URI
  • https://doi.org/10.32604/chd.2020.011512DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Left-to-right shunt in sinus venosus septal defect (SVSD) may affect resistive (pulmonary vascular resistance-PVR) and elastic (pulmonary artery compliance-PAC) pulmonary artery properties. This study aimed at evaluating (1) impact of age, (2) pulmonary hemodynamics, and (3) outcome in a large cohort of SVSD patients. Methods: This study included 136 patients with SVSD (median age at diagnosis 14 (IQR 5-48) years, 47% male) of which 87 underwent catheterization. Pressures were measured and cardiac output was evaluated using the Fick principle at diagnosis. PVR, PAC and their product (RC time) were calculated. Results: Surgical repair was performed in 128 (94%) at a median age of 13 (IQR 5- 43) years. During a median follow-up time of 31 (IQR 17-55) years, 12 (9%) patients died, 13 (10%) developed heart failure, 4 (3%) Eisenmenger syndrome, 19 (14%) atrial arrhythmia, 6 (4%) sick sinus syndrome and 7 (5%) required pacemaker implantation In those who underwent catheterization, median shunt ratio was 2.5 (IQR 2.0-2.9). Thirty (34%) had mean PA pressure >= 25 mmHg. PVR indexed, PAC indexed, and RC time was 3.5 (IQR 2.4-7.5) WU.m(2) , 1.8 (IQR 1.3-2.5) mL/mmHg.m(2) and 0.39 (0.26-0.53) sec with an inverse hyperbolic relationship between PVR and PAC. Mean PA pressure (P < 0.0001); wedge pressure (P = 0.001), PVR indexed (P = 0.002) and PAC indexed (P = 0.002) changed significantly with age at diagnosis, but shunt ratio did not. Conclusion: SVSD has good long-term outcome, albeit with late morbidities. Thirty-four percent has mean PA pressure >= 25 mmHg, but Eisenmenger syndrome is rare (3%). PVR and PAC are inversely related and change significantly with older age.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Santens, B. (author)
  • Troost, E. (author)
  • De Meester, P. (author)
  • Roggen, L. (author)
  • Rega, F. (author)
  • Meyns, B. (author)
  • Cools, B. (author)
  • Gewillig, M. (author)
  • Moons, Philip,1968Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences(Swepub:gu)xmooph (author)
  • Meier, L. (author)
  • Budts, W. (author)
  • Van de Bruaene, A. (author)
  • Göteborgs universitetInstitutionen för vårdvetenskap och hälsa (creator_code:org_t)

Related titles

  • In:Congenital Heart Disease: Computers, Materials and Continua (Tech Science Press)15:2, s. 69-781747-079X

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view