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Low serum DHEA-S is...
Low serum DHEA-S is associated with impaired lung function in women
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Pesce, G. (author)
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Triebner, K. (author)
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van der Plaat, D. A. (author)
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Courbon, D. (author)
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Hustad, S. (author)
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Sigsgaard, T. (author)
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Nowak, D. (author)
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Heinrich, J. (author)
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Anto, J. M. (author)
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Dorado-Arenas, S. (author)
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Martinez-Moratalla, J. (author)
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Gullon-Blanco, J. A. (author)
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Sanchez-Ramos, J. L. (author)
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Raherison, C. (author)
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Pin, I. (author)
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Demoly, P. (author)
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Gislason, T. (author)
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- Torén, Kjell, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Forsberg, Bertil (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Lindberg, Eva (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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Zemp, E. (author)
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- Jõgi, Rain (author)
- Lung Clinic, Tartu University Hospital, Tartu, Estonia
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Probst-Hensch, N. (author)
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Dharmage, S. C. (author)
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Jarvis, D. (author)
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Garcia-Aymerich, J. (author)
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Marcon, A. (author)
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Gómez-Real, F. (author)
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Leynaert, B. (author)
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: EClinicalMedicine. - : Elsevier BV. - 2589-5370. ; 23
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Abstract
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- Background: Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS). Methods: Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999–2002 and in 2010–2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999–2002 with incidence of restrictive pattern and airflow limitation in 2010–2013 were also assessed. Findings: Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14). Interpretation: Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health. Funding: EU H2020, grant agreement no.633212 © 2020 The Authors
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Airflow obstruction
- Androgens
- Cohort studies
- Sex hormones
- Airflow obstruction
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pesce, G.
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Triebner, K.
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van der Plaat, D ...
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Courbon, D.
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Hustad, S.
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Sigsgaard, T.
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show more...
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Nowak, D.
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Heinrich, J.
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Anto, J. M.
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Dorado-Arenas, S ...
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Martinez-Moratal ...
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Gullon-Blanco, J ...
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Sanchez-Ramos, J ...
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Raherison, C.
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Pin, I.
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Demoly, P.
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Gislason, T.
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Torén, Kjell, 19 ...
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Forsberg, Bertil
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Lindberg, Eva
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Zemp, E.
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Jõgi, Rain
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Probst-Hensch, N ...
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Dharmage, S. C.
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Jarvis, D.
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Garcia-Aymerich, ...
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Marcon, A.
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Gómez-Real, F.
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Leynaert, B.
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Occupational Hea ...
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MEDICAL AND HEAL ...
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and Respiratory Medi ...
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EClinicalMedicin ...
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University of Gothenburg
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Uppsala University
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Umeå University