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- Li, B. B. (author)
The effect of vitamin D supplementation in treatment of children with autism spectrum disorder: a systematic review and meta-analysis of randomized controlled trials
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2020-09-07
- Informa UK Limited,2022
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- LIBRIS-ID:oai:gup.ub.gu.se/297096
- https://gup.ub.gu.se/publication/297096URI
- https://doi.org/10.1080/1028415x.2020.1815332DOI
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- Language:English
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- Objective:The effect of vitamin D supplementation on the risk of Autism Spectrum Disorder (ASD) is conflicting. The aim of this study was to estimate the efficacy of vitamin D supplementation on ASD in children. Methods:We conducted a meta-analysis of randomized controlled trials (RCTs) in which vitamin D supplementation was used as a therapy in children with ASD. The PubMed, PsychINFO, Cochrane CENTRAL library, Web of Science, and Cinahl databases were searched from inception to March 20, 2019, for all publications on vitamin D and ASD with no restrictions. Studies involving individuals aged <18 years diagnosed with ASD and with all functional outcomes assessed by measurement scales for ASD were included. Mean differences were pooled, and a meta-analysis was performed using a random-effects model due to differences between the individual RCTs. Results:There were five RCTs with 349 children with ASD in the review, of which three RCTs were included in the meta-analysis. Vitamin D supplementation indicated a small but significant improvement in hyperactivity scores (pooled MD: -3.20; 95% CI: [-6.06, -0.34]) with low heterogeneity (I-2 = 10%,p = 0.33), but there were no other statistically significant differences in ASD symptoms between groups as measured by validated scales. Conclusion:Vitamin D supplementation appears to be beneficial for hyperactivity but not for core symptoms or other co-existing behaviors and conditions of ASD. Future RCTs with large sample sizes examining the effect of vitamin D supplementation on ASD among individuals with low serum vitamin D levels at baseline are needed.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Vitamin D supplementation
- autism spectrum disorders
- children
- randomized controlled trials
- meta-analysis
- systematic review
- hyperactivity
- docosahexaenoic acid
- core symptoms
- environmental-factors
- 25-hydroxyvitamin d
- tolerability
- efficacy
- Neurosciences & Neurology
- Nutrition & Dietetics
Added entries (persons, corporate bodies, meetings, titles ...)
- Xu, Y. R. (author)
- Zhang, X. L. (author)
- Zhang, L. L. (author)
- Wu, Y. A. (author)
- Wang, X. Y.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology (author)
- Zhu, Changlian,1964Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation(Swepub:gu)xzhuch (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)
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- In:Nutritional Neuroscience: Informa UK Limited25:4, s. 835-8451028-415X1476-8305
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