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Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival
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- Axelsson, Lars (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar,Institute of Clinical Sciences, Department of Otorhinolaryngology,Department of Otorhinolaryngology, University of Gothenburg Sahlgrenska Academy, Goteborg, Sweden; Department of Otorhinolaryngology - Head and Neck Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Dept Otorhinolaryngol, Grona Straket 9, S-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Gothenburg, Sweden.
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- Holmberg, Erik, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Regional Cancer Center in Western Sweden, Gothenburg, Sweden; Department of Oncology, University of Gothenburg Sahlgrenska Academy, Gothenburg, Sweden,Reg Canc Ctr Western Sweden, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Dept Oncol, Gothenburg, Sweden.
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- Nyman, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Department of Oncology, University of Gothenburg Sahlgrenska Academy, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Dept Oncol, Gothenburg, Sweden.
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- (creator_code:org_t)
- 2020-09-30
- 2021
- English.
- In: International Archives of Otorhinolaryngology. - : Georg Thieme Verlag KG. - 1809-9777 .- 1809-4864. ; 25:3
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPVpositive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p = 0.036), and N stage (p = 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and ( chemo) radiation and primary (chemo)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- head and neck cancer
- cancer of unknown primary
- prognostic factors
- human papillomavirus
- treatment
- lymph-node metastases
- squamous-cell carcinoma
- contemporary management
- primary tumor
- primary site
- radiotherapy
- modality
- surgery
- Otorhinolaryngology
- head and neck cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Nyman, Jan, 1956
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- Ekberg, Thomas
- Farnebo, Lovisa
- Talani, Charbél
- Spak, L. N.
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