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Blood extracellular...
Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age
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Grenier-Pleau, I. (author)
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Tyryshkin, K. (author)
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Le, T. D. (author)
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Rudan, J. (author)
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Bonneil, E. (author)
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Thibault, P. (author)
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Zeng, K. R. (author)
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- Lässer, Cecilia, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Krefting Research Centre,Institute of Medicine
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Mallinson, D. (author)
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Lamprou, D. (author)
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Hui, J. L. (author)
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Postovit, L. M. (author)
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Chan, E. Y. W. (author)
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Abraham, S. A. (author)
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(creator_code:org_t)
- 2020-10-07
- 2020
- English.
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In: Aging Cell. - : Wiley. - 1474-9718 .- 1474-9726. ; 19:11
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Abstract
Subject headings
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- Hematopoietic stem cells (HSCs) maintain balanced blood cell production in a process called hematopoiesis. As humans age, their HSCs acquire mutations that allow some HSCs to disproportionately contribute to normal blood production. This process, known as age-related clonal hematopoiesis, predisposes certain individuals to cancer, cardiovascular and pulmonary pathologies. There is a growing body of evidence suggesting that factors outside cells, such as extracellular vesicles (EVs), contribute to the disruption of stem cell homeostasis during aging. We have characterized blood EVs from humans and determined that they are remarkably consistent with respect to size, concentration, and total protein content, across healthy subjects aged 20-85 years. When analyzing EV protein composition from mass spectroscopy data, our machine-learning-based algorithms are able to distinguish EV proteins based on age and suggest that different cell types dominantly produce EVs released into the blood, which change over time. Importantly, our data show blood EVs from middle and older age groups (>40 years) significantly stimulate HSCs in contrast to untreated and EVs sourced from young subjects. Our study establishes for the first time that although EV particle size, concentration, and total protein content remain relatively consistent over an adult lifespan in humans, EV content evolves during aging and potentially influences HSC regulation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- aging
- clonal hematopoiesis
- exosomes
- extracellular vesicles
- hematopoiesis
- hematopoietic stem cells
- tolerance
- Cell Biology
- Geriatrics & Gerontology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Aging Cell
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To the university's database
- By the author/editor
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Grenier-Pleau, I ...
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Tyryshkin, K.
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Le, T. D.
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Rudan, J.
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Bonneil, E.
-
Thibault, P.
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show more...
-
Zeng, K. R.
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Lässer, Cecilia, ...
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Mallinson, D.
-
Lamprou, D.
-
Hui, J. L.
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Postovit, L. M.
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Chan, E. Y. W.
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Abraham, S. A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Aging Cell
- By the university
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University of Gothenburg