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Terminal complement...
Terminal complement complex formation is associated with intervertebral disc degeneration
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2020-09-16
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Springer Science and Business Media LLC,2021
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LIBRIS-ID:oai:gup.ub.gu.se/297265
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https://gup.ub.gu.se/publication/297265URI
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https://doi.org/10.1007/s00586-020-06592-4DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Purpose The complement system is a crucial part of innate immunity. Recent work demonstrated an unexpected contribution to tissue homeostasis and degeneration. This study investigated for the first time, in human disc tissues, the deposition profile of the complement activation product terminal complement complex (TCC), an inflammatory trigger and inducer of cell lysis, and its inhibitor CD59, and their correlation with the degree of disc degeneration (DD). Methods Disc biopsies were collected from patients diagnosed with DD (n = 39, age 63 +/- 12) and adolescent idiopathic scoliosis (AIS,n = 10, age 17 +/- 4) and compared with discs from healthy Young (n = 11, age 7 +/- 7) and Elder (n = 10, age 65 +/- 15) donors. Immunohistochemical detection of TCC and CD59 in nucleus pulposus (NP), annulus fibrosus (AF) and endplate (EP) was correlated with age, Pfirrmann grade and Modic changes. Results Higher percentage of TCC+ cells was detected in the NP and EP of DD compared to Elder (P < 0.05), and in the EP of Young versus Elder (P < 0.001). In DD, TCC deposition was positively correlated with Pfirrmann grade, but not with Modic changes, whereas for Young donors, a negative correlation was found with age, indicating TCC's involvement not only in DD, but also in early stages of skeletal development. Higher CD59 positivity was found in AIS and DD groups compared to Young (P < 0.05), and it was negatively correlated with the age of the patients. Conclusion TCC deposition positively correlated with the degree of disc degeneration. A functional relevance of TCC may exist in DD, representing a potential target for new therapeutics.
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Yong, Z. Y.
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Goncalves, R. M.
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Kuhn, A.
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Riegger, J.
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Brisby, Helena,1965Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics(Swepub:gu)xbrish
(author)
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Barreto Henriksson, HelenaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics(Swepub:gu)xbarhe
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Ruf, M.
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Nerlich, A.
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Mauer, U. M.
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Ignatius, A.
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Brenner, R. E.
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Neidlinger-Wilke, C.
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för ortopedi
(creator_code:org_t)
Related titles
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In:European Spine Journal: Springer Science and Business Media LLC30, s. 217-2260940-67191432-0932
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Teixeira, G. Q.
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Yong, Z. Y.
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Goncalves, R. M.
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Kuhn, A.
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Riegger, J.
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Brisby, Helena, ...
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Barreto Henrikss ...
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Ruf, M.
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Nerlich, A.
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Mauer, U. M.
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Ignatius, A.
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Brenner, R. E.
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Neidlinger-Wilke ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
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European Spine J ...
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University of Gothenburg