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Mortality risk in i...
Mortality risk in irritable bowel syndrome: Results from a nationwide prospective cohort study
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- Staller, K. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston Massachusetts, USA
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- Olén, O. (author)
- Karolinska Institutet
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- Söderling, J. (author)
- Karolinska Institutet
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- Roelstraete, B. (author)
- Karolinska Institutet
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- Törnblom, Hans, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Institute of Medicine, University of Gothenberg, Gothenberg, Sweden
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- Khalili, H. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston Massachusetts, USA
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- Joshi, A. D. (author)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston Massachusetts, USA
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- Nguyen, L. H. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston Massachusetts, USA
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- Song, M. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston Massachusetts, USA; Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Boston Massachusetts, USA
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- Kuo, B. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA
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- Chan, A. T. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston Massachusetts, USA
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2020-02-28
- 2020
- English.
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In: American Journal of Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 0002-9270 .- 1572-0241. ; 115:5, s. 746-755
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Abstract
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- INTRODUCTION: Mortality concern is a frequent driver of care seeking in patients with irritable bowel syndrome (IBS). Data on mortality in IBS are scarce, and population-based studies have been limited in size. We examined mortality in IBS. METHODS: A nationwide, matched, population-based cohort study was conducted in Sweden. We identified 45,524 patients undergoing a colorectal biopsy at any of Sweden’s 28 pathology departments and with a diagnosis of IBS from 2002 to 2016 according to the National Patient Register, a nationwide registry of inpatient and outpatient specialty care. We compared the mortality risk between these individuals with IBS and age- and sex-matched reference individuals (n 5 217,316) from the general population and siblings (n 5 53,228). In separate analyses, we examined the role of mucosal appearance for mortality in IBS. Finally, we examined mortality in 41,427 patients with IBS not undergoing a colorectal biopsy. Cox regression estimated hazard ratios (HRs) for death. RESULTS: During follow-up, there were 3,290 deaths in individuals with IBS (9.4/1,000 person-years) compared with 13,255 deaths in reference individuals (7.9/1,000 person-years), resulting in an HR of 1.10 (95% confidence interval [CI] 5 1.05–1.14). After adjustment for confounders, IBS was not linked to mortality (HR 5 0.96; 95% CI 5 0.92–1.00). The risk estimates were neutral when patients with IBS were compared with their siblings. The underlying mucosal appearance on biopsy had only a marginal impact on mortality, and patients with IBS not undergoing a colorectal biopsy were at no increased risk of death (HR 5 1.02; 95% CI 5 0.99–1.06). DISCUSSION: IBS does not seem to confer an increased risk of death. Copyright © 2020 by The American College of Gastroenterology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- adult
- biopsy
- cause of death
- clinical trial
- epidemiology
- female
- follow up
- health survey
- human
- irritable colon
- male
- middle aged
- mortality
- multicenter study
- procedures
- prospective study
- risk assessment
- risk factor
- survival rate
- Sweden
- Follow-Up Studies
- Humans
- Irritable Bowel Syndrome
- Population Surveillance
- Prospective Studies
- Risk Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Staller, K.
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Olén, O.
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Söderling, J.
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Roelstraete, B.
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Törnblom, Hans, ...
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Khalili, H.
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show more...
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Joshi, A. D.
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Nguyen, L. H.
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Song, M.
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Kuo, B.
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Chan, A. T.
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Ludvigsson, Jona ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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American Journal ...
- By the university
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University of Gothenburg
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Örebro University
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Karolinska Institutet