Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.

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Fältnamn	Indikatorer	Metadata
000		12256naa a2201489 4500
001		oai:gup.ub.gu.se/297596
003		SwePub
008		240528s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:uu-424065
009		oai:lup.lub.lu.se:9a451a80-186c-48e3-984d-ad6861a35aa6
009		oai:prod.swepub.kib.ki.se:145007830
024	7	a https://gup.ub.gu.se/publication/2975962 URI
024	7	a https://doi.org/10.1038/s42255-020-00287-22 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4240652 URI
024	7	a https://lup.lub.lu.se/record/9a451a80-186c-48e3-984d-ad6861a35aa62 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1450078302 URI
040		a (SwePub)gud (SwePub)uud (SwePub)lud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Folkersen, Lasseu Danish National Genome Center4 aut
245	1 0	a Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
264		c 2020-10-16
264	1	b Springer Science and Business Media LLC,c 2020
500		a De tre första författarna delar förstaförfattarskapetDe tre sista författarna delar sistaförfattarskapet
520		a Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Gustafsson, Stefanu Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi4 aut0 (Swepub:lu)extLU-1433
700	1	a Wang, Qinu University of Oulu4 aut
700	1	a Hansen, Daniel Hvidbergu Intomics A/S4 aut
700	1	a Hedman, Åsa Ku Karolinska Institutet,Karolinska Institute,Pfizer Limited, UK4 aut
700	1	a Schork, Andrewu Translational Genomics Research Institute (TGen)4 aut
700	1	a Page, Karenu Pfizer Inc. US4 aut
700	1	a Zhernakova, Daria Vu University of Groningen4 aut
700	1	a Wu, Yangu University of Queensland4 aut
700	1	a Peters, Jamesu Imperial College London,University of Cambridge4 aut
700	1	a Eriksson, Niclas,d 1978-u Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)nieri103
700	1	a Bergen, Sarah Eu Karolinska Institutet,Karolinska Institute4 aut
700	1	a Boutin, Thibaud Su University of Edinburgh4 aut
700	1	a Bretherick, Andrew Du SCALLOP consortium4 aut
700	1	a Enroth, Stefan,d 1976-u Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Gyllensten4 aut0 (Swepub:uu)stenr451
700	1	a Kalnapenkis, Anetteu SCALLOP consortium4 aut
700	1	a Gådin, Jesper Ru Karolinska Institutet4 aut
700	1	a Suur, Bianca Eu Karolinska Institutet4 aut
700	1	a Chen, Yanu Karolinska Institutet,Karolinska Institute4 aut
700	1	a Matic, Ljubicau Karolinska Institutet4 aut
700	1	a Gale, Jeremy Du SCALLOP consortium4 aut
700	1	a Lee, Julieu SCALLOP consortium4 aut
700	1	a Zhang, Weidongu SCALLOP consortium4 aut
700	1	a Quazi, Amirau SCALLOP consortium4 aut
700	1	a Ala-Korpela, Mikau SCALLOP consortium4 aut
700	1	a Choi, Seung Hoanu SCALLOP consortium4 aut
700	1	a Claringbould, Anniqueu SCALLOP consortium4 aut
700	1	a Danesh, Johnu SCALLOP consortium4 aut
700	1	a Davey Smith, Georgeu SCALLOP consortium4 aut
700	1	a de Masi, Federicou SCALLOP consortium4 aut
700	1	a Elmståhl, Sölveu Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-sel
700	1	a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-gen
700	1	a Fauman, Eric4 aut
700	1	a Fernandez, Celineu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medk-cfe
700	1	a Franke, Lude4 aut
700	1	a Franks, Paul Wu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
700	1	a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517
700	1	a Haley, Chris4 aut
700	1	a Hamsten, Andersu Karolinska Institutet4 aut
700	1	a Ingason, Andres4 aut
700	1	a Johansson, Åsau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik4 aut0 (Swepub:uu)asjoh108
700	1	a Joshi, Peter K4 aut
700	1	a Lind, Larsu Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind
700	1	a Lindgren, Cecilia Mu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cardiovascular Research - Hypertension,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)medf-mma
700	1	a Lubitz, Steven4 aut
700	1	a Palmer, Tom4 aut
700	1	a Macdonald-Dunlop, Erin4 aut
700	1	a Nilsson, Peter Mu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-pni
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ome
700	1	a Michaëlsson, Karl,d 1959-u Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)karlmich
700	1	a Morris, Andrew P4 aut
700	1	a Mägi, Reedik4 aut
700	1	a Nagle, Michael W4 aut
700	1	a Nilsson, Peter M4 aut
700	1	a Nilsson, Janu Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-jni
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
700	1	a Polasek, Ozren4 aut
700	1	a Prins, Bram4 aut
700	1	a Pålsson, Erik4 aut
700	1	a Qi, Ting4 aut
700	1	a Sjögren, Marketau Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genetic and Molecular Epidemiology,Lund University Research Groups,Cardiovascular Research - Hypertension,Skåne University Hospital4 aut0 (Swepub:lu)endo-msj
700	1	a Sundström, Johan,c Professor,d 1971-u Uppsala universitet,Klinisk epidemiologi,The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia4 aut0 (Swepub:uu)johasund
700	1	a Surendran, Praveen4 aut
700	1	a Võsa, Urmo4 aut
700	1	a Werge, Thomas4 aut
700	1	a Wernersson, Rasmus4 aut
700	1	a Westra, Harm-Jan4 aut
700	1	a Yang, Jian4 aut
700	1	a Zhernakova, Alexandra4 aut
700	1	a Ärnlöv, Johanu Karolinska Institutet4 aut
700	1	a Fu, Jingyuan4 aut
700	1	a Smith, Gustavu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine4 aut0 (Swepub:lu)med-gvs
700	1	a Esko, Tõnu4 aut
700	1	a Hayward, Caroline4 aut
700	1	a Gyllensten, Ulfu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik4 aut0 (Swepub:uu)ulfgyll
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Siegbahn, Agneta,d 1947-u Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)agsie424
700	1	a Wilson, James F4 aut
700	1	a Wallentin, Lars,d 1943-u Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
700	1	a Butterworth, Adam S4 aut
700	1	a Holmes, Michael V4 aut
700	1	a Ingelsson, Erik4 aut
700	1	a Mälarstig, Andersu Karolinska Institutet4 aut
710	2	a Danish National Genome Centerb Science for Life Laboratory, SciLifeLab4 org
773	0	t Nature metabolismd : Springer Science and Business Media LLCg 2:10, s. 1135-1148q 2:10<1135-1148x 2522-5812
856	4	u https://pure.rug.nl/ws/files/194787127/Genomic_and_drug_target_evaluation_of_90_cardiovascular_proteins_in_30_931_individuals.pdf
856	4	u https://portal.research.lu.se/files/100206750/Folkersen_2020.pdfx primaryx freey FULLTEXT
856	4	u http://dx.doi.org/10.1038/s42255-020-00287-2y FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/297596
856	4 8	u https://doi.org/10.1038/s42255-020-00287-2
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-424065
856	4 8	u https://lup.lub.lu.se/record/9a451a80-186c-48e3-984d-ad6861a35aa6
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:145007830

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By the author/editor: Folkersen, Lasse; Gustafsson, Stef ...; Wang, Qin; Hansen, Daniel H ...; Hedman, Åsa K; Schork, Andrew; show more...; Page, Karen; Zhernakova, Dari ...; Wu, Yang; Peters, James; Eriksson, Niclas ...; Bergen, Sarah E; Boutin, Thibaud ...; Bretherick, Andr ...; Enroth, Stefan, ...; Kalnapenkis, Ane ...; Gådin, Jesper R; Suur, Bianca E; Chen, Yan; Matic, Ljubica; Gale, Jeremy D; Lee, Julie; Zhang, Weidong; Quazi, Amira; Ala-Korpela, Mik ...; Choi, Seung Hoan; Claringbould, An ...; Danesh, John; Davey Smith, Geo ...; de Masi, Federic ...; Elmståhl, Sölve; Engström, Gunnar; Fauman, Eric; Fernandez, Celin ...; Franke, Lude; Franks, Paul W; Giedraitis, Vilm ...; Haley, Chris; Hamsten, Anders; Ingason, Andres; Johansson, Åsa; Joshi, Peter K; Lind, Lars; Lindgren, Cecili ...; Lubitz, Steven; Palmer, Tom; Macdonald-Dunlop ...; Nilsson, Peter M; Melander, Olle; Michaëlsson, Kar ...; Morris, Andrew P; Mägi, Reedik; Nagle, Michael W; Nilsson, Jan; Orho-Melander, M ...; Polasek, Ozren; Prins, Bram; Pålsson, Erik; Qi, Ting; Sjögren, Marketa; Sundström, Johan ...; Surendran, Prave ...; Võsa, Urmo; Werge, Thomas; Wernersson, Rasm ...; Westra, Harm-Jan; Yang, Jian; Zhernakova, Alex ...; Ärnlöv, Johan; Fu, Jingyuan; Smith, Gustav; Esko, Tõnu; Hayward, Carolin ...; Gyllensten, Ulf; Landén, Mikael, ...; Siegbahn, Agneta ...; Wilson, James F; Wallentin, Lars, ...; Butterworth, Ada ...; Holmes, Michael ...; Ingelsson, Erik; Mälarstig, Ander ...; show less...

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