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- Martin, W. P. (author)
Obesity is common in chronic kidney disease and associates with greater antihypertensive usage and proteinuria: evidence from a cross-sectional study in atertiary nephrology centre
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-08-26
- Wiley,2020
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- LIBRIS-ID:oai:gup.ub.gu.se/297788
- https://gup.ub.gu.se/publication/297788URI
- https://doi.org/10.1111/cob.12402DOI
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- Language:English
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- Obesity is a treatable risk factor for chronic kidney disease progression. We audited the reporting of body-mass index in nephrology outpatient clinics to establish the characteristics of individuals with obesity in nephrology practice. Body-mass index, clinical information and biochemical measures were recorded for patients attending clinics between 3(rd)August, 2018 and 18(th)January, 2019. Inferential statistics and Pearson correlations were used to investigate relationships between body-mass index, type 2 diabetes, hypertension and proteinuria. Mean +/- SD BMI was 28.6 +/- 5.8 kg/m(2)(n = 374). Overweight and obesity class 1 were more common in males (P= .02). Amongst n = 123 individuals with obesity and chronic kidney disease, mean +/- SD age, n (%) female and median[IQR] eGFR were 64.1 +/- 14.2 years, 52 (42.3%) and 29.0[20.5] mL/min/BSA, respectively. A positive correlation between increasing body-mass index and proteinuria was observed in such patients (r= 0.21,P= .03), which was stronger in males and those with CKD stages 4 and 5. Mean body-mass index was 2.3 kg/m(2)higher in those treated with 4-5 versus 0-1 antihypertensives (P= .03). Amongst n = 59 patients with obesity, chronic kidney disease and type 2 diabetes, 2 (3.5%) and 0 (0%) were prescribed a GLP-1 receptor analogue and SGLT2-inhibitor, respectively. Our data provides a strong rationale not only for measuring body-mass index but also for acting on the information in nephrology practice, although prospective studies are required to guide treatment decisions in people with obesity and chronic kidney disease.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- chronic kidney disease
- diabetes mellitus
- diabetic kidney disease
- obesity
- overweight
- bariatric surgery
- sglt2 inhibitors
- outcomes
- glomerulopathy
- liraglutide
- mortality
- trials
- Endocrinology & Metabolism
Added entries (persons, corporate bodies, meetings, titles ...)
- Bauer, J. (author)
- Coleman, J. (author)
- Dellatorre-Teixeira, L. (author)
- Reeve, J. L. V. (author)
- Twomey, P. J. (author)
- Docherty, Neil G.Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xdocme (author)
- O'Riordan, A. (author)
- Watson, A. J. (author)
- le Roux, Carel WGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xleroc (author)
- Göteborgs universitetInstitutionen för kliniska vetenskaper (creator_code:org_t)
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- In:Clinical Obesity: Wiley10:61758-81031758-8111
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