Search: onr:"swepub:oai:gup.ub.gu.se/297888" >
A longitudinal exam...
A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease
-
Sugarman, M. A. (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
show more...
-
Tripodis, Y. (author)
-
McKee, A. C. (author)
-
Stein, T. D. (author)
-
Martin, B. (author)
-
Palmisano, J. N. (author)
-
Steinberg, E. G. (author)
-
Simkin, I. (author)
-
Budson, A. E. (author)
-
Killiany, R. (author)
-
O'Connor, M. K. (author)
-
Au, R. (author)
-
Qiu, W. W. Q. (author)
-
Goldstein, L. E. (author)
-
Kowall, N. W. (author)
-
Mez, J. (author)
-
Stern, R. A. (author)
-
Alosco, M. L. (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
-
In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 94, s. 60-70
- Related links:
-
https://europepmc.or...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- We examined baseline and longitudinal associations between plasma neurofilament light (NfL) and total tau (t-tau), and the clinical presentation of Alzheimer's disease (AD). A total of 579 participants (238, normal cognition [NC]; 185, mild cognitive impairment [MCI]; 156, AD dementia) had baseline blood draws; 82% had follow-up evaluations. Plasma samples were analyzed for NfL and t-tau using Simoa technology. Baseline plasma NfL was higher in AD dementia than MCI (standardized mean difference = 0.55, 95% CI: 0.37–0.73) and NC (standardized mean difference = 0.68, 95% CI: 0.49–0.88), corresponded to Clinical Dementia Rating scores (OR = 1.94, 95% CI: 1.35–2.79]), and correlated with all neuropsychological tests (r's = 0.13–0.42). Longitudinally, NfL did not predict diagnostic conversion but predicted decline on 3/10 neuropsychological tests. Baseline plasma t-tau was higher in AD dementia than NC with a small effect (standardized mean difference = 0.33, 95% CI: 0.10–0.57) but not MCI. t-tau did not statistically significant predict any longitudinal outcomes. Plasma NfL may be useful for the detection of AD dementia and monitoring of disease progression. In contrast, there was minimal evidence in support of plasma t-tau. © 2020 Elsevier Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Neurofilament light
- Plasma biomarkers
- Total tau
- neurofilament protein
- tau protein
- age distribution
- aged
- Alzheimer disease
- Article
- blood sampling
- Clinical Dementia Rating
- cognition assessment
- controlled study
- dementia
- disease course
- educational status
- female
- follow up
- human
- longitudinal study
- major clinical study
- male
- mild cognitive impairment
- Mini Mental State Examination
- neuropsychological test
- priority journal
- protein analysis
- protein blood level
- sex difference
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sugarman, M. A.
-
Zetterberg, Henr ...
-
Blennow, Kaj, 19 ...
-
Tripodis, Y.
-
McKee, A. C.
-
Stein, T. D.
-
show more...
-
Martin, B.
-
Palmisano, J. N.
-
Steinberg, E. G.
-
Simkin, I.
-
Budson, A. E.
-
Killiany, R.
-
O'Connor, M. K.
-
Au, R.
-
Qiu, W. W. Q.
-
Goldstein, L. E.
-
Kowall, N. W.
-
Mez, J.
-
Stern, R. A.
-
Alosco, M. L.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Neurobiology of ...
- By the university
-
University of Gothenburg