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- Elmegiri, M. (author)
MRI Characterization of Non-traumatic Intracerebral Hemorrhage in Young Adults
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-10-29
- Frontiers Media SA,2020
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- LIBRIS-ID:oai:gup.ub.gu.se/298312
- https://gup.ub.gu.se/publication/298312URI
- https://doi.org/10.3389/fneur.2020.558680DOI
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- Language:English
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- Background and Purpose: Non-traumatic intracerebral hemorrhage (ICH) in younger population is a relatively rare event but is associated with considerable mortality and poor functional outcome. Imaging plays a crucial role in determining the underlying cause and guide treatment of ICH. In up to 41% of patients in prior studies, the underlying cause remained elusive. However, the usage of MRI as part of diagnostic work-up was scanty. We aimed to analyze MRI findings of ICH in younger patients and assess specificity and sensitivity of MRI in detecting structural or local underlying causes of ICH. Methods: We included patients aged 15-49 years with first-ever ICH identified from a prospective hospital discharge registry, 2000-2010. All study patients underwent MRI within 3 months of ICH. Imaging data was analyzed by a senior neuroradiologist blinded to final clinical diagnosis. We calculated the diagnostic accuracy of MRI in detecting structural/local underlying causes. Results: Of our 116 patients (median age, 39; 67% males), structural/local causes were the leading causes of ICH (50.0%), and of these, bleeding cavernomas (23.3%) were the most frequent followed by arteriovenous malformations (12.9%), cerebral venous thrombosis (CVT) (7.8%), brain tumors (5.2%), and moyamoya disease (0.9%). Lobar location of ICH was more prevalent in younger patients. MRI was highly sensitive (90.0%; 95% confidence interval, 79.5-96.2%) for detection of structural/local causes compared with angiographic imaging (55.6%; 95% CI, 40.0-70.4%), while MRI was less specific (87.3%; 95% CI, 75.5-94.7%) for structural/local causes, compared with angiographic imaging (97.4%; 95% CI, 86.5-99.9%). Conclusion: MRI was highly sensitive for the detection of structural and local causes underlying ICH in young adults. Thus, MRI should be considered in the diagnostic work-up of all young ICH patients to enable targeted secondary prevention.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- spontaneous intracerebral hemorrhage
- young adults
- magnetic resonance
- imaging
- structural cause
- cavernoma
- cerebral microbleeds
- risk-factors
- stroke
- angiography
- management
- diagnosis
- Neurosciences & Neurology
Added entries (persons, corporate bodies, meetings, titles ...)
- Koivunen, R. J. (author)
- Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xtatlt (author)
- Putaala, J. (author)
- Martola, J. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap (creator_code:org_t)
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- In:Frontiers in Neurology: Frontiers Media SA111664-2295
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