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Clinical presentati...
Clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy: an ESC EORP registry.
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Sliwa, Karen (author)
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Petrie, Mark C (author)
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van der Meer, Peter (author)
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Mebazaa, Alexandre (author)
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Hilfiker-Kleiner, Denise (author)
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Jackson, Alice M (author)
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Maggioni, Aldo P (author)
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Laroche, Cecile (author)
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Regitz-Zagrosek, Vera (author)
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- Schaufelberger, Maria, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Tavazzi, Luigi (author)
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Roos-Hesselink, Jolien W (author)
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Seferovic, Petar (author)
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van Spaendonck-Zwarts, Karin (author)
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Mbakwem, Amam (author)
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Böhm, Michael (author)
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Mouquet, Frederic (author)
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Pieske, Burkert (author)
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Johnson, Mark R (author)
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Hamdan, Righab (author)
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Ponikowski, Piotr (author)
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Van Veldhuisen, Dirk J (author)
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McMurray, John J V (author)
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Bauersachs, Johann (author)
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(creator_code:org_t)
- 2020-08-25
- 2020
- English.
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In: European heart journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 41:39, s. 3787-3797
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Abstract
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- We sought to describe the clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy (PPCM) globally.In 2011, >100 national and affiliated member cardiac societies of the European Society of Cardiology (ESC) were contacted to contribute to a global registry on PPCM, under the auspices of the ESC EURObservational Research Programme. These societies were tasked with identifying centres who could participate in this registry. In low-income countries, e.g. Mozambique or Burkina Faso, where there are no national societies due to a shortage of cardiologists, we identified potential participants through abstracts and publications and encouraged participation into the study. Seven hundred and thirty-nine women were enrolled in 49 countries in Europe (33%), Africa (29%), Asia-Pacific (15%), and the Middle East (22%). Mean age was 31±6years, mean left ventricular ejection fraction (LVEF) was 31±10%, and 10% had a previous pregnancy complicated by PPCM. Symptom-onset occurred most often within 1month of delivery (44%). At diagnosis, 67% of patients had severe (NYHA III/IV) symptoms and 67% had a LVEF ≤35%. Fifteen percent received bromocriptine with significant regional variation (Europe 15%, Africa 26%, Asia-Pacific 8%, the Middle East 4%, P<0.001). Follow-up was available for 598 (81%) women. Six-month mortality was 6% overall, lowest in Europe (4%), and highest in the Middle East (10%). Most deaths were due to heart failure (42%) or sudden (30%). Re-admission for any reason occurred in 10% (with just over half of these for heart failure) and thromboembolic events in 7%. Myocardial recovery (LVEF > 50%) occurred only in 46%, most commonly in Asia-Pacific (62%), and least commonly in the Middle East (25%). Neonatal death occurred in 5% with marked regional variation (Europe 2%, the Middle East 9%).Peripartum cardiomyopathy is a global disease, but clinical presentation and outcomes vary by region. Just under half of women experience myocardial recovery. Peripartum cardiomyopathy is a disease with substantial maternal and neonatal morbidity and mortality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sliwa, Karen
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Petrie, Mark C
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van der Meer, Pe ...
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Mebazaa, Alexand ...
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Hilfiker-Kleiner ...
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Jackson, Alice M
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show more...
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Maggioni, Aldo P
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Laroche, Cecile
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Regitz-Zagrosek, ...
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Schaufelberger, ...
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Tavazzi, Luigi
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Roos-Hesselink, ...
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Seferovic, Petar
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van Spaendonck-Z ...
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Mbakwem, Amam
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Böhm, Michael
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Mouquet, Frederi ...
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Pieske, Burkert
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Johnson, Mark R
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Hamdan, Righab
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Ponikowski, Piot ...
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Van Veldhuisen, ...
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McMurray, John J ...
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Bauersachs, Joha ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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European heart j ...
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University of Gothenburg