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Automated Nocicepti...
Automated Nociceptive Withdrawal Reflex Measurements Reveal Normal Reflex Thresholds and Augmented Pain Ratings in Patients with Fibromyalgia.
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- Ydrefors, Johannes (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Neurofysiologiska kliniken US
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- Karlsson, Tomas, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,University of Gothenburg, Gothenburg, Sweden
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- Wentzel Olausson, Ulrika (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Ghafouri, Bijar, 1972- (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Johansson, Ann-Charlotte, 1976- (author)
- Linköpings universitet,Medicinska fakulteten,Centrum för social och affektiv neurovetenskap
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- Olausson, Håkan, 1965- (author)
- Linköpings universitet,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Centrum för social och affektiv neurovetenskap,Region Östergötland, Neurofysiologiska kliniken US
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- Gerdle, Björn, 1953- (author)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för prevention, rehabilitering och nära vård,Region Östergötland, Smärt och rehabiliteringscentrum
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- Nagi, Saad (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Neurofysiologiska kliniken US
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(creator_code:org_t)
- 2020-06-25
- 2020
- English.
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In: Journal of clinical medicine. - Switzerland : MDPI AG. - 2077-0383. ; 9:6
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https://doi.org/10.3...
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The nociceptive withdrawal reflex (NWR) is used to probe spinal cord excitability in chronic pain states. Here, we used an automated and unbiased procedure for determining the NWR threshold and compared the reflex thresholds and corresponding pain ratings in a well-characterized cohort of fibromyalgia (n = 29) and matched healthy controls (n = 21). Surface electrical stimuli were delivered to the foot in a stepwise incremental and decremental manner. The surface electromyographic activity was recorded from the ipsilateral tibialis anterior muscle. Fibromyalgia patients reported significantly higher scores for psychological distress and pain-related disability and a significantly lower score for perceived state of health compared to the matched controls. The subjective pain ratings were significantly higher in patients. The NWR thresholds were similar to the controls. In the patients, but not in controls, the NWR thresholds and subjective pain ratings were significantly correlated. Our results showed an increased subjective pain sensitivity in fibromyalgia, but we found no evidence for spinal sensitization based on the reflex measures.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- chronic pain
- electromyography
- fibromyalgia
- nociceptive withdrawal reflex
- sensitization
- chronic pain; electromyography; fibromyalgia; nociceptive withdrawal reflex; sensitization
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ydrefors, Johann ...
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Karlsson, Tomas, ...
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Wentzel Olausson ...
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Ghafouri, Bijar, ...
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Johansson, Ann-C ...
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Olausson, Håkan, ...
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Gerdle, Björn, 1 ...
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Nagi, Saad
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of clini ...
- By the university
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University of Gothenburg
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Linköping University