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No changes in HIV s...
No changes in HIV suppression and inflammatory markers in CSF in patients randomly switched to DTG + 3TC (Spanish HIV/AIDS Research Network, PreEC/RIS 62).
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Tiraboschi, Juan M (author)
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Rojas, Jhon (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Niubo, Jordi (author)
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Gostner, Johanna (author)
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Navarro-Alcaraz, Antonio (author)
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Piatti, Camila (author)
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Fuchs, Dietmar (author)
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- Gisslén, Magnus, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Rigo-Bonnin, Raul (author)
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Martinez, Esteban (author)
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Podzamczer, Daniel (author)
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(creator_code:org_t)
- 2020-10-13
- 2021
- English.
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In: The Journal of infectious diseases. - : Oxford University Press (OUP). - 1537-6613 .- 0022-1899. ; 223:11, s. 1928-1933
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Abstract
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- A major concern of HIV dual therapy is a potential lower efficacy in viral reservoirs, especially in the central nervous system (CNS). We evaluated HIV RNA, neuronal injury and inflammatory biomarkers and dolutegravir (DTG) exposure in cerebrospinal fluid (CSF) in patients switching to DTG+lamivudine (3TC). All participants maintained viral suppression in plasma and CSF at week 48. We observed no increase in CSF markers of inflammation or neuronal injury. Median (IQR) total and unbound DTG in CSF were 7.3(5.9-8.4) ng/mL and 1.7(1.2-1.9) ng/mL, respectively. DTG+3TC may maintain viral control without changes in inflammatory/injury markers within the CNS reservoir.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Tiraboschi, Juan ...
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Rojas, Jhon
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Niubo, Jordi
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Gostner, Johanna
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show more...
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Navarro-Alcaraz, ...
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Piatti, Camila
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Fuchs, Dietmar
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Gisslén, Magnus, ...
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Rigo-Bonnin, Rau ...
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Martinez, Esteba ...
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Podzamczer, Dani ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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The Journal of i ...
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University of Gothenburg