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Cerebrospinal fluid...
Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease.
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- Visser, Pieter Jelle (author)
- Karolinska Institutet
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Reus, Lianne M (author)
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- Gobom, Johan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Jansen, Iris (author)
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Dicks, Ellen (author)
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Tsolaki, Magda (author)
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Verhey, Frans R J (author)
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Popp, Julius (author)
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Martinez-Lage, Pablo (author)
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Vandenberghe, Rik (author)
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Lleó, Alberto (author)
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Molinuevo, José Luís (author)
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Engelborghs, Sebastiaan (author)
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Freund-Levi, Yvonne (author)
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Froelich, Lutz (author)
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Sleegers, Kristel (author)
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Dobricic, Valerija (author)
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Hong, Shengjun (author)
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Lovestone, Simon (author)
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Streffer, Johannes (author)
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Vos, Stephanie J B (author)
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Bos, Isabelle (author)
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Smit, August B (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Scheltens, Philip (author)
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Teunissen, Charlotte E (author)
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Bertram, Lars (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Tijms, Betty M (author)
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(creator_code:org_t)
- Cold Spring Harbor Laboratory, 2020
- 2020
- English.
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In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
- Related links:
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Alzheimer's disease (AD) is characterised by abnormal amyloid beta and tau processing. Previous studies reported that cerebrospinal fluid (CSF) total tau (t-tau) levels vary between patients. Here we show that CSF t-tau variability is associated with distinct impairments in neuronal plasticity mediated by gene repression factors SUZ12 and REST. AD individuals with abnormal t-tau levels have increased CSF concentrations of plasticity proteins regulated by SUZ12 and REST. AD individuals with normal t-tau, on the contrary, have decreased concentrations of these plasticity proteins and increased concentrations in proteins associated with blood-brain and blood CSF-barrier dysfunction. Genomic analyses suggested that t-tau levels in part depend on genes involved in gene expression. The distinct plasticity abnormalities in AD as signaled by t-tau urge the need for personalised treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Visser, Pieter J ...
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Reus, Lianne M
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Gobom, Johan
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Jansen, Iris
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Dicks, Ellen
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Tsolaki, Magda
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show more...
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Verhey, Frans R ...
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Popp, Julius
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Martinez-Lage, P ...
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Vandenberghe, Ri ...
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Lleó, Alberto
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Molinuevo, José ...
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Engelborghs, Seb ...
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Freund-Levi, Yvo ...
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Froelich, Lutz
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Sleegers, Kriste ...
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Dobricic, Valeri ...
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Hong, Shengjun
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Lovestone, Simon
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Streffer, Johann ...
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Vos, Stephanie J ...
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Bos, Isabelle
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Smit, August B
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Blennow, Kaj, 19 ...
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Scheltens, Phili ...
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Teunissen, Charl ...
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Bertram, Lars
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Zetterberg, Henr ...
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Tijms, Betty M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
- medRxiv : the pr ...
- By the university
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University of Gothenburg
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Karolinska Institutet