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Concordance of CSF ...
Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays.
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Keshavan, Ashvini (author)
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Wellington, Henrietta (author)
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Chen, Zhongbo (author)
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Khatun, Ayesha (author)
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Chapman, Miles (author)
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Hart, Melanie (author)
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Cash, David M (author)
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Coath, William (author)
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Parker, Thomas D (author)
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Buchanan, Sarah M (author)
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Keuss, Sarah E (author)
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Harris, Matthew J (author)
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Murray-Smith, Heidi (author)
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Heslegrave, Amanda (author)
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Fox, Nick C (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Schott, Jonathan M (author)
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(creator_code:org_t)
- 2020-09-13
- 2020
- English.
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In: Alzheimer's & dementia (Amsterdam, Netherlands). - : Wiley. - 2352-8729. ; 12:1
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- We assessed the concordance of cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau measured on the fully automated Lumipulse platform with pre-symptomatic Alzheimer's disease (AD) pathology on amyloid positron emission tomography (PET).In 72 individuals from the Insight 46 study, CSF Aβ40, Aβ42, total tau (t-tau), and phosphorylated tau at site 181 (p-tau181) were measured using Lumipulse, INNOTEST, and Meso Scale Discovery (MSD) assays, and inter-platform Pearson correlations were derived. Logistic regressions and receiver-operating characteristic analysis generated CSF cut-points optimizing concordance with 18F-florbetapir amyloid PET status (n=63).Measurements of CSF Aβ, p-tau181, and their ratios correlated well across platforms (r 0.84-.94, P<.0001); those of t-tau and t-tau/Aβ42 correlated moderately (r 0.57-0.79, P<.0001). The best concordance with amyloid PET (100% sensitivity and 94% specificity) was afforded by cut-points of 0.110 for Lumipulse Aβ42/Aβ40, 0.087 for MSD Aβ42/Aβ40, and 25.3 for Lumipulse Aβ42/p-tau181.The Lumipulse platform provides comparable sensitivity and specificity to established CSF immunoassays in identifying pre-symptomatic AD pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Keshavan, Ashvin ...
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Wellington, Henr ...
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Chen, Zhongbo
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Khatun, Ayesha
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Chapman, Miles
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Hart, Melanie
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show more...
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Cash, David M
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Coath, William
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Parker, Thomas D
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Buchanan, Sarah ...
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Keuss, Sarah E
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Harris, Matthew ...
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Murray-Smith, He ...
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Heslegrave, Aman ...
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Fox, Nick C
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Zetterberg, Henr ...
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Schott, Jonathan ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's & de ...
- By the university
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University of Gothenburg