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First amyloid β1-42...
First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays
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Boulo, S. (author)
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Kuhlmann, J. (author)
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- Andreasson, Ulf, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Brix, B. (author)
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Venkataraman, I. (author)
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Herbst, V. (author)
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Rutz, S. (author)
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Manuilova, E. (author)
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Vandijck, M. (author)
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Dekeyser, F. (author)
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- Bjerke, Maria, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Pannee, Josef, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Charoud-Got, J. (author)
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Auclair, G. (author)
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Mazoua, S. (author)
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Pinski, G. (author)
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Trapmann, S. (author)
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Schimmel, H. (author)
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Emons, H. (author)
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Quaglia, M. (author)
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- Portelius, Erik, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Korecka, M. (author)
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Shaw, L. M. (author)
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Lame, M. (author)
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Chambers, E. (author)
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Vanderstichele, H. (author)
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Stoops, E. (author)
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Leinenbach, A. (author)
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Bittner, T. (author)
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Jenkins, R. G. (author)
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Kostanjevecki, V. (author)
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Lewczuk, P. (author)
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- Gobom, Johan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Zegers, I. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2020-08-04
- 2020
- English.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 16:11, s. 1493-1503
- Related links:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Introduction: Reference materials based on human cerebrospinal fluid were certified for the mass concentration of amyloid beta (Aβ)1-42 (Aβ42). They are intended to be used to calibrate diagnostic assays for Aβ42. Methods: The three certified reference materials (CRMs), ERM-DA480/IFCC, ERM-DA481/IFCC and ERM-DA482/IFCC, were prepared at three concentration levels and characterized using isotope dilution mass spectrometry methods. Roche, EUROIMMUN, and Fujirebio used the three CRMs to re-calibrate their immunoassays. Results: The certified Aβ42 mass concentrations in ERM-DA480/IFCC, ERM-DA481/IFCC, and ERM-DA482/IFCC are 0.45, 0.72, and 1.22μg/L, respectively, with expanded uncertainties (k=2) of 0.07, 0.11, and 0.18μg/L, respectively. Before re-calibration, a good correlation (Pearson's r>0.97), yet large biases, were observed between results from different commercial assays. After re-calibration the between-assay bias was reduced to<5%. Discussion: The Aβ42 CRMs can ensure the equivalence of results between methods and across platforms for the measurement of Aβ42. © 2020 the Alzheimer's Association
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid beta peptide
- certified reference material
- commercial immunoassays
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Boulo, S.
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Kuhlmann, J.
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Andreasson, Ulf, ...
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Brix, B.
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Venkataraman, I.
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Herbst, V.
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show more...
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Rutz, S.
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Manuilova, E.
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Vandijck, M.
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Dekeyser, F.
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Bjerke, Maria, 1 ...
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Pannee, Josef, 1 ...
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Charoud-Got, J.
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Auclair, G.
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Mazoua, S.
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Pinski, G.
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Trapmann, S.
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Schimmel, H.
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Emons, H.
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Quaglia, M.
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Portelius, Erik, ...
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Korecka, M.
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Shaw, L. M.
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Lame, M.
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Chambers, E.
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Vanderstichele, ...
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Stoops, E.
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Leinenbach, A.
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Bittner, T.
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Jenkins, R. G.
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Kostanjevecki, V ...
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Lewczuk, P.
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Gobom, Johan
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Zetterberg, Henr ...
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Zegers, I.
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Blennow, Kaj, 19 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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University of Gothenburg