Spotlight on microRNAs in allergy and asthma

Weidner, Julie,1983Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Krefting Research Centre,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition (author)

In past 10 years, microRNAs (miRNAs) have gained scientific attention due to their importance in the pathophysiology of allergic diseases and their potential as biomarkers in liquid biopsies. They act as master post-transcriptional regulators that control most cellular processes. As one miRNA can target several mRNAs, often within the same pathway, dysregulated expression of miRNAs may alter particular cellular responses and contribute, or lead, to the development of various diseases. In this review, we give an overview of the current research on miRNAs in allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma. Specifically, we discuss how individual miRNAs function in the regulation of immune responses in epithelial cells and specialized immune cells in response to different environmental factors and respiratory viruses. In addition, we review insights obtained from experiments with murine models of allergic airway and skin inflammation and offer an overview of studies focusing on miRNA discovery using profiling techniques and bioinformatic modeling of the network effect of multiple miRNAs. In conclusion, we highlight the importance of research into miRNA function in allergy and asthma to improve our knowledge of the molecular mechanisms involved in the pathogenesis of this heterogeneous group of diseases.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
allergic disease
asthma
experimental models
microRNA
pollution
bronchial epithelial-cells
smooth-muscle-cells
influenza-a virus
airway eosinophilic inflammation
diesel exhaust particles
tobacco-smoke exposure
innate lymphoid-cells
atopic-dermatitis
chronic rhinosinusitis
circulating micrornas
Allergy
Immunology

Bartel, S. (author)
Kilic, A. (author)
Zissler, U. M. (author)
Renz, H. (author)
Schwarze, J. (author)
Schmidt-Weber, C. B. (author)
Maes, T. (author)
Rebane, A. (author)
Krauss-Etschmann, S. (author)
Rådinger, Madeleine,1967Gothenburg University,Göteborgs universitet,Krefting Research Centre,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xradim (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (creator_code:org_t)

By the author/editor: Weidner, Julie, ...; Bartel, S.; Kilic, A.; Zissler, U. M.; Renz, H.; Schwarze, J.; show more...; Schmidt-Weber, C ...; Maes, T.; Rebane, A.; Krauss-Etschmann ...; Rådinger, Madele ...; show less...

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